Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | APEX1 | P27695 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bicarbonate SCHEMBL6473409 | 0.95 | CA1 (0.50) | CA1CA2CA9APEX1 | |
| Hydrogen Peroxide SCHEMBL7011640 | 0.91 | — | — | |
| Bicarbonate SCHEMBL11882345 | 0.86 | — | — | |
| Bicarbonate SCHEMBL9663662 | 0.86 | CA1 (0.60) | CA1CA2CA9APEX1 | |
| Bicarbonate SCHEMBL28650116 | 0.86 | CA1 (0.60) | CA1CA2CA9APEX1 | |
| SCHEMBL6751047 | 0.85 | — | — | |
| SCHEMBL301246 | 0.85 | — | — | |
| Hydrogen Peroxide SCHEMBL5297349 | 0.85 | — | — | |
| SCHEMBL28045378 | 0.85 | — | — | |
| Bicarbonate SCHEMBL11674981 | 0.82 | CA1 (0.55) | CA1CA2CA9APEX1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1411522-A | Enzymatic process for dyeing with vat and sulphur dyes | NOVOZYMES BIOTECH INC (US) | 2003-04-16 | — | — | CN | disclosed |
| EP-1153166-A2 | ENZYMATIC METHODS FOR DYEING WITH REDUCED VAT AND SULFUR DYES | Novozymes Biotech, Inc. (US) | 2001-11-14 | — | — | EP | disclosed |
| US-6129769-A | OXIDIZING THE REDUCED DYES WITH AN OXIDATION SYSTEM COMPRISING AN OXYGEN SOURCE AND OXIDASE ACTIVITY ENZYMES OR A HYDROGEN PEROXIDE SOURCE AND PEROXIDASE ACTIVITY ENZYMES, CONVERTING TO FORM OXIDIZED INSOLUBLE COLORED FORMS | NOVO NORDISK BIOTECH, INC. (US) | 2000-10-10 | — | — | US | disclosed |
| WO-2000031333-A2 | ENZYMATIC METHODS FOR DYEING WITH REDUCED VAT AND SULFUR DYES | NOVOZYMES BIOTECH, INC. (US) | 2000-06-02 | — | — | WO | disclosed |
| US-5948122-A | Enzymatic methods for dyeing with reduced vat and sulfur dyes | NOVO NORDISK BIOTECH, INC. (US) | 1999-09-07 | — | — | US | disclosed |