Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAF1 | P04049 | 7/20 | 0.61 |
| ▸ | MAPK14 | Q16539 | 10/20 | 0.53 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.46 |
| ▸ | CXCR2 | P25025 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3217455 | 0.87 | RAF1 (0.80) | RAF1MAPK14PKMATMALDH1A1 | |
| SCHEMBL3244702 | 0.79 | MAPK14 (0.77) | RAF1MAPK14 | |
| SCHEMBL14159658 | 0.78 | RAF1 (0.78) | RAF1MAPK14PKMATMALDH1A1 | |
| SCHEMBL15959532 | 0.77 | RAF1 (0.83) | RAF1MAPK14PKMATMALDH1A1 | |
| SCHEMBL2926566 | 0.76 | RAF1 (1.00) | RAF1MAPK14PKMATMALDH1A1 | |
| SCHEMBL14159719 | 0.75 | MAPK14 (0.66) | RAF1MAPK14PKMATMALDH1A1 | |
| SCHEMBL15298832 | 0.74 | RAF1 (0.75) | RAF1MAPK14PKMATMALDH1A1 | |
| SCHEMBL1275920 | 0.71 | ALDH1A1 (0.70) | ALDH1A1MEN1LMNAMAPTHTT | |
| SCHEMBL16920251 | 0.70 | NPC1 (0.66) | ALDH1A1MEN1MAPTHPGDKMT2A | |
| SCHEMBL366747 | 0.68 | SMN1; SMN2 (0.74) | ALDH1A1MEN1LMNAMAPTHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050256174-A1 | Raf kinase inhibitors | BAYER HEALTHCARE LLC | 2005-11-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050256174-A1 | Raf kinase inhibitors | BRAF, RAF1, ARAF | RAF1 2/4885MAPK14 239/4885PKM 1684/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.