Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 9/20 | 0.61 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.44 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.42 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | C3AR1 | Q16581 | 1/20 | 0.38 |
| ▸ | GNAI3 | P08754 | 1/20 | 0.38 |
| ▸ | GNAO1 | P09471 | 1/20 | 0.38 |
| ▸ | GNAI1 | P63096 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14086762 | 0.84 | EPHX1 (0.59) | EPHX1POLBSIGMAR1CHRM5CHRM3 | |
| SCHEMBL7502098 | 0.78 | EPHX1 (0.57) | EPHX1POLBSIGMAR1CHRM5CHRM3 | |
| SCHEMBL8232157 | 0.76 | EPHX1 (1.00) | EPHX1POLBSIGMAR1CHRM5CHRM3 | |
| SCHEMBL7427277 | 0.76 | EPHX1 (1.00) | EPHX1POLBSIGMAR1CHRM5CHRM3 | |
| SCHEMBL21575131 | 0.75 | EPHX1 (0.41) | EPHX1SIGMAR1CHRM5CHRM3NPC1 | |
| SCHEMBL8365416 | 0.75 | HTR1E (0.61) | MAPTCYP3A4TSHRHTTC3AR1 | |
| SCHEMBL255421 | 0.75 | EPHX1 (0.59) | EPHX1POLBSIGMAR1EPHX2GNAI3 | |
| SCHEMBL19086797 | 0.75 | EPHX1 (0.59) | EPHX1POLBSIGMAR1CHRM5CHRM3 | |
| SCHEMBL15733339 | 0.74 | EPHX1 (0.96) | EPHX1POLBSIGMAR1CHRM5CHRM3 | |
| SCHEMBL24323730 | 0.73 | POLB (0.81) | EPHX1POLBRAB9AEPHX2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6867192-B1 | Compounds useful in the treatment of inflammatory diseases | GLAXO GROUP LIMITED (GB) | 2005-03-15 | — | — | US | disclosed |
| EP-1140837-B1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LTD (GB) | 2004-08-18 | — | — | EP | disclosed |
| CN-1330637-A | Compounds useful in treatment of infammatory diseases | GLAXO GROUP LTD (GB) | 2002-01-09 | — | — | CN | disclosed |
| EP-1140837-A1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000037444-A1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2000-06-29 | — | — | WO | disclosed |