Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | PTPN1 | P18031 | 8/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.42 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.42 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6474262 | 0.84 | KMT2A (0.51) | KMT2AALDH1A1ITGB1ITGA4ITGB7 | |
| SCHEMBL29398078 | 0.82 | PTPN1 (0.58) | PTPN1 | |
| SCHEMBL2735616 | 0.82 | PTPN1 (0.58) | PTPN1 | |
| SCHEMBL6480346 | 0.82 | PSMB11 (0.46) | PTPN1ITGB1ITGA4ITGB7 | |
| SCHEMBL7377139 | 0.81 | ITGB1 (0.49) | KMT2AITGB1ITGA4ITGB7 | |
| SCHEMBL31524127 | 0.81 | ITGB1 (0.49) | KMT2AITGB1ITGA4ITGB7 | |
| SCHEMBL6532390 | 0.80 | CASP1 (0.49) | KMT2AALDH1A1ITGB1ITGA4ITGB7 | |
| SCHEMBL30490552 | 0.79 | PTPN1 (0.59) | PTPN1 | |
| SCHEMBL29561412 | 0.79 | PTPN1 (0.59) | PTPN1 | |
| SCHEMBL30490542 | 0.79 | PTPN1 (0.59) | PTPN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6867192-B1 | Compounds useful in the treatment of inflammatory diseases | GLAXO GROUP LIMITED (GB) | 2005-03-15 | — | — | US | disclosed |
| EP-1140837-B1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LTD (GB) | 2004-08-18 | — | — | EP | disclosed |
| EP-1140837-A1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000037444-A1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2000-06-29 | — | — | WO | disclosed |