Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CACNA1B | Q00975 | 7/20 | 0.48 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | YAP1 | P46937 | 2/20 | 0.42 |
| ▸ | REN | P00797 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.40 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.40 |
| ▸ | ITGB7 | P26010 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7535034 | 1.00 | CACNA1B (0.48) | CACNA1BHPGDMAPK1ALDH1A1LMNA | |
| SCHEMBL7536860 | 0.90 | CACNA1B (0.50) | CACNA1BMAPK1ALDH1A1LMNAYAP1 | |
| SCHEMBL6479164 | 0.90 | CACNA1B (0.50) | CACNA1BMAPK1ALDH1A1LMNAYAP1 | |
| Hydrochloric Acid SCHEMBL6480368 | 0.90 | CACNA1B (0.49) | CACNA1BMAPK1ALDH1A1LMNAYAP1 | |
| Hydrochloric Acid SCHEMBL7540812 | 0.90 | CACNA1B (0.49) | CACNA1BMAPK1ALDH1A1LMNAYAP1 | |
| SCHEMBL6473065 | 0.85 | MAPK1 (0.52) | CACNA1BMAPK1YAP1 | |
| Hydrochloric Acid SCHEMBL6691609 | 0.85 | CACNA1B (0.45) | CACNA1BMAPK1ALDH1A1LMNAYAP1 | |
| Hydrochloric Acid SCHEMBL6691605 | 0.85 | CACNA1B (0.45) | CACNA1BMAPK1ALDH1A1LMNAYAP1 | |
| SCHEMBL6686538 | 0.84 | CACNA1B (0.49) | CACNA1BYAP1KMT2AMEN1ITGB1 | |
| SCHEMBL6481358 | 0.84 | CACNA1B (0.49) | CACNA1BYAP1KMT2AMEN1ITGB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6867192-B1 | Compounds useful in the treatment of inflammatory diseases | GLAXO GROUP LIMITED (GB) | 2005-03-15 | — | — | US | disclosed |
| EP-1140837-B1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LTD (GB) | 2004-08-18 | — | — | EP | disclosed |
| EP-1140837-A1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000037444-A1 | COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATORY DISEASES | GLAXO GROUP LIMITED (GB) | 2000-06-29 | — | — | WO | disclosed |