SCHEMBL6474332

SCHEMBL6474332

O=C(O)CCc1ccc(OCC=C(c2ccc(F)cc2)c2ccc(F)cc2)cc1

nearest known ligand 0.77

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
PPARD Q03181 9/20 0.77
PPARG P37231 7/20 0.59
PPARA Q07869 7/20 0.59
FFAR1 O14842 7/20 0.54
FFAR4 Q5NUL3 3/20 0.52
NR4A2 P43354 1/20 0.49
LMNA P02545 1/20 0.49
L3MBTL1 Q9Y468 1/20 0.49
ESR1 P03372 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6474183 0.87 PPARD (0.77) PPARDPPARGPPARAFFAR1FFAR4
SCHEMBL6480506 0.87 PPARD (1.00) PPARDPPARGPPARAFFAR1FFAR4
SCHEMBL6482041 0.87 PPARD (0.77) PPARDPPARGPPARAFFAR1FFAR4
SCHEMBL6475122 0.86 PPARD (0.76) PPARDPPARGPPARANR4A2LMNA
SCHEMBL6475704 0.86 PPARD (0.72) PPARDPPARGPPARAFFAR1FFAR4
SCHEMBL6527568 0.86 PPARD (0.75) PPARDPPARGPPARAFFAR1FFAR4
SCHEMBL6474386 0.85 PPARD (0.73) PPARDPPARGPPARAFFAR1FFAR4
SCHEMBL6475148 0.81 PPARD (0.62) PPARDPPARGPPARAFFAR1FFAR4
SCHEMBL6480185 0.81 PPARD (0.58) PPARDPPARGPPARAFFAR1FFAR4
SCHEMBL6474071 0.81 FFAR1 (0.55) PPARDPPARGPPARAFFAR1FFAR4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6869967-B2 Peroxisome proliferator-activated receptor (PPAR) active vinyl carboxylic acid derivatives NOVO NORDISK A/S (DK) 2005-03-22 US claimed
US-20030139473-A1 Novel compounds, their preparation and use VTVX HOLDINGS II LLC 2003-07-24 US claimed
US-6869967-B2 Peroxisome proliferator-activated receptor (PPAR) active vinyl carboxylic acid derivatives NOVO NORDISK A/S (DK) 2005-03-22 US disclosed
US-20030139473-A1 Novel compounds, their preparation and use VTVX HOLDINGS II LLC 2003-07-24 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030139473-A1 Novel compounds, their preparation and use PPARG, PPARD, PPARA PPARD 2/4885PPARG 1/4885PPARA 3/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.