Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 17/20 | 0.69 |
| ▸ | SMO | Q99835 | 1/20 | 0.65 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | RAF1 | P04049 | 1/20 | 0.49 |
| ▸ | BRAF | P15056 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7107912 | 0.96 | MAPK14 (0.64) | MAPK14SMOOPRK1MEN1NPC1 | |
| SCHEMBL6485519 | 0.87 | MAPK14 (0.89) | MAPK14SMOMEN1KMT2ARAF1 | |
| SCHEMBL6782804 | 0.87 | MAPK14 (0.73) | MAPK14SMONPC1RAB9ARAF1 | |
| SCHEMBL6487036 | 0.86 | MAPK14 (0.66) | MAPK14SMOOPRK1MEN1NPC1 | |
| SCHEMBL6486377 | 0.85 | MAPK14 (0.63) | MAPK14SMOOPRK1MEN1NPC1 | |
| SCHEMBL6476015 | 0.85 | MAPK14 (0.65) | MAPK14SMOOPRK1MEN1NPC1 | |
| SCHEMBL6477567 | 0.85 | MAPK14 (0.62) | MAPK14SMOOPRK1RAF1BRAF | |
| SCHEMBL6484389 | 0.82 | MAPK14 (0.70) | MAPK14SMORAB9ARAF1BRAF | |
| SCHEMBL6478056 | 0.82 | MAPK14 (0.68) | MAPK14SMORAB9ARAF1BRAF | |
| SCHEMBL6476258 | 0.82 | OPRK1 (0.62) | MAPK14SMOOPRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6956037-B2 | Benzamide derivatives for the treatment of diseases mediated by cytokines | ASTRAZENECA AB (SE) | 2005-10-18 | — | — | US | disclosed |
| EP-1077931-B1 | BENZAMIDE DERIVATIVES FOR THE TREATMENT OF DISEASES MEDIATED BY CYTOKINES | ASTRAZENECA AB (SE) | 2004-11-17 | — | — | EP | disclosed |
| US-6579872-B1 | Such as TNF, in particular of TNF alpha, and various interleukins, in particular IL-1; N-(5-(4-(3-hydroxypropoxy)benzamido)-2-methylphenyl)-3,4-dimethoxybenzamide | ASTRAZENECA AB (SE) | 2003-06-17 | — | — | US | disclosed |