Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.65 |
| ▸ | POLB | P06746 | 3/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | HRH3 | Q9Y5N1 | 11/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | MAOB | P27338 | 1/20 | 0.51 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3576150 | 0.86 | KDM4E (0.56) | KDM4EALDH1A1SMN1; SMN2POLBKMT2A | |
| SCHEMBL6472573 | 0.82 | HRH3 (0.72) | KDM4EALDH1A1SMN1; SMN2POLBKMT2A | |
| SCHEMBL3577103 | 0.82 | HRH3 (0.61) | KDM4EALDH1A1SMN1; SMN2HRH3MAPT | |
| SCHEMBL6471511 | 0.81 | KDM4E (0.62) | KDM4EALDH1A1SMN1; SMN2KMT2AMEN1 | |
| SCHEMBL22638122 | 0.81 | FFAR4 (0.54) | KDM4EALDH1A1SMN1; SMN2POLBMAPT | |
| SCHEMBL3590220 | 0.81 | HRH3 (0.60) | KDM4EALDH1A1SMN1; SMN2HRH3 | |
| SCHEMBL3585244 | 0.79 | HRH3 (0.71) | KDM4EALDH1A1SMN1; SMN2POLBKMT2A | |
| Hydrochloric Acid SCHEMBL4235034 | 0.79 | KDM4E (0.71) | KDM4EALDH1A1SMN1; SMN2POLBKMT2A | |
| SCHEMBL6471513 | 0.79 | HRH3 (0.75) | ALDH1A1HRH3MAPT | |
| SCHEMBL7564110 | 0.77 | KDM4E (0.82) | KDM4EALDH1A1SMN1; SMN2POLBHRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1567511-A1 | SUBSTITUTED PIPERAZINES, (1,4) DIASZEPINES, AND 2,5-DIAZABICYCLO (2.2.1) HEPTANES AS HISTAMINE H1 AND/OR H3 ANTAGONISTS OR HISTAMINE H3 REVERSE ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2005-08-31 | — | — | EP | disclosed |
| WO-2004035556-A1 | SUBSTITUTED PIPERAZINES, (1,4) DIASZEPINES, AND 2,5-DIAZABICYCLO (2.2.1) HEPTANES AS HISTAMINE H1 AND/OR H3 ANTAGONISTS OR HISTAMINE H3 REVERSE ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2004-04-29 | — | — | WO | disclosed |