Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.59 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.59 |
| ▸ | RAB9A | P51151 | 1/20 | 0.59 |
| ▸ | CTSL | P07711 | 4/20 | 0.57 |
| ▸ | CTSS | P25774 | 4/20 | 0.57 |
| ▸ | CTSB | P07858 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | CTSK | P43235 | 3/20 | 0.53 |
| ▸ | CASP3 | P42574 | 2/20 | 0.48 |
| ▸ | SYK | P43405 | 1/20 | 0.47 |
| ▸ | MME | P08473 | 1/20 | 0.46 |
| ▸ | ECE1 | P42892 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3740379 | 1.00 | CYP3A4 (0.59) | CYP3A4CYP2D6CYP2C9CYP2C19RAB9A | |
| SCHEMBL3731597 | 0.92 | CYP3A4 (0.59) | CYP3A4CYP2D6CYP2C9CYP2C19RAB9A | |
| SCHEMBL3740281 | 0.91 | CTSB (0.50) | CYP3A4CYP2D6CYP2C9CYP2C19RAB9A | |
| SCHEMBL3728988 | 0.91 | CTSB (0.50) | CYP3A4CYP2D6CYP2C9CYP2C19RAB9A | |
| SCHEMBL3727409 | 0.90 | CYP3A4 (0.62) | CYP3A4CYP2D6CYP2C9CYP2C19RAB9A | |
| SCHEMBL3729765 | 0.90 | CYP3A4 (0.62) | CYP3A4CYP2D6CYP2C9CYP2C19RAB9A | |
| SCHEMBL3735186 | 0.89 | CYP3A4 (0.54) | CYP3A4CYP2D6CYP2C9CYP2C19RAB9A | |
| SCHEMBL3735857 | 0.87 | CYP3A4 (0.57) | CYP3A4CYP2D6CYP2C9CYP2C19RAB9A | |
| SCHEMBL3732258 | 0.87 | CYP3A4 (0.57) | CYP3A4CYP2D6CYP2C9CYP2C19RAB9A | |
| SCHEMBL3735858 | 0.87 | CYP3A4 (0.57) | CYP3A4CYP2D6CYP2C9CYP2C19RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6974802-B2 | Treatment of viral infections using prodrugs of 2′,3-dideoxy,3′-fluoroguanosine | MEDIVIR AB (SE) | 2005-12-13 | — | — | US | disclosed |
| US-6458772-B1 | Prodrugs | MEDIVIR AB (SE) | 2002-10-01 | — | — | US | disclosed |