Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 16/20 | 0.58 |
| ▸ | ERBB2 | P04626 | 14/20 | 0.58 |
| ▸ | FECH | P22830 | 1/20 | 0.58 |
| ▸ | CDK8 | P49336 | 1/20 | 0.58 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.58 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.58 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.58 |
| ▸ | ERBB3 | P21860 | 5/20 | 0.49 |
| ▸ | ERBB4 | Q15303 | 5/20 | 0.49 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.47 |
| ▸ | RIPK3 | Q9Y572 | 1/20 | 0.47 |
| ▸ | PIP4K2A | P48426 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6476813 | 1.00 | EGFR (0.58) | EGFRERBB2FECHCDK8MAP2K5 | |
| SCHEMBL6476818 | 0.92 | EGFR (0.58) | EGFRERBB2FECHCDK8MAP2K5 | |
| SCHEMBL6483503 | 0.91 | ERBB2 (0.68) | EGFRERBB2FECHCDK8MAP2K5 | |
| SCHEMBL4618422 | 0.89 | EGFR (0.61) | EGFRERBB2FECHCDK8MAP2K5 | |
| SCHEMBL4618427 | 0.89 | EGFR (0.61) | EGFRERBB2FECHCDK8MAP2K5 | |
| SCHEMBL4618941 | 0.87 | EGFR (0.60) | EGFRERBB2FECHCDK8MAP2K5 | |
| SCHEMBL2990203 | 0.85 | EGFR (0.57) | EGFRERBB2FECHCDK8MAP2K5 | |
| SCHEMBL6175305 | 0.84 | EGFR (0.63) | EGFRERBB2FECHCDK8MAP2K5 | |
| SCHEMBL4617012 | 0.84 | EGFR (0.71) | EGFRERBB2FECHCDK8MAP2K5 | |
| SCHEMBL6175312 | 0.84 | EGFR (0.63) | EGFRERBB2FECHCDK8MAP2K5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6890924-B2 | Substituted bicyclic derivatives for the treatment of abnormal cell growth | PFIZER INC (US) | 2005-05-10 | — | — | US | disclosed |