Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ERBB2 | P04626 | 15/20 | 0.68 |
| ▸ | EGFR | P00533 | 11/20 | 0.68 |
| ▸ | FECH | P22830 | 2/20 | 0.68 |
| ▸ | CDK8 | P49336 | 1/20 | 0.68 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.68 |
| ▸ | CDK19 | Q9BWU1 | 1/20 | 0.68 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.68 |
| ▸ | ERBB3 | P21860 | 1/20 | 0.60 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.60 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.49 |
| ▸ | RIPK3 | Q9Y572 | 2/20 | 0.44 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NQO2 | P16083 | 1/20 | 0.44 |
| ▸ | MYH14 | Q7Z406 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6476808 | 0.91 | EGFR (0.58) | ERBB2EGFRFECHCDK8MAP2K5 | |
| SCHEMBL6476813 | 0.91 | EGFR (0.58) | ERBB2EGFRFECHCDK8MAP2K5 | |
| SCHEMBL6173028 | 0.88 | ERBB2 (0.75) | ERBB2EGFRFECHCDK8MAP2K5 | |
| SCHEMBL6173015 | 0.88 | ERBB2 (0.75) | ERBB2EGFRFECHCDK8MAP2K5 | |
| SCHEMBL4617788 | 0.88 | ERBB2 (0.72) | ERBB2EGFRFECHCDK8MAP2K5 | |
| SCHEMBL4799703 | 0.88 | ERBB2 (0.72) | ERBB2EGFRFECHCDK8MAP2K5 | |
| SCHEMBL4617348 | 0.88 | ERBB2 (0.72) | ERBB2EGFRFECHCDK8MAP2K5 | |
| SCHEMBL4962435 | 0.88 | ERBB2 (0.71) | ERBB2EGFRFECHCDK8MAP2K5 | |
| SCHEMBL4962447 | 0.88 | ERBB2 (0.71) | ERBB2EGFRFECHCDK8MAP2K5 | |
| SCHEMBL4962734 | 0.87 | ERBB2 (0.73) | ERBB2EGFRFECHCDK8MAP2K5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6890924-B2 | Substituted bicyclic derivatives for the treatment of abnormal cell growth | PFIZER INC (US) | 2005-05-10 | — | — | US | disclosed |