Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 8/20 | 0.43 |
| ▸ | CCNC | P24863 | 1/20 | 0.41 |
| ▸ | CDK8 | P49336 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 7/20 | 0.40 |
| ▸ | FLT4 | P35916 | 7/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | PDK2 | Q15119 | 2/20 | 0.38 |
| ▸ | EGFR | P00533 | 10/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 6/20 | 0.37 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.37 |
| ▸ | ITK | Q08881 | 2/20 | 0.37 |
| ▸ | RET | P07949 | 2/20 | 0.36 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.36 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.36 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.36 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.36 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL6477543 | 0.80 | KDR (0.43) | KDRFLT1FLT4EGFRFGFR1 | |
| SCHEMBL5411249 | 0.78 | KDR (0.62) | KDRFLT1FLT4EGFRFGFR1 | |
| Hydrochloric Acid SCHEMBL6462102 | 0.77 | KDR (0.61) | KDRFLT1FLT4EGFRFGFR1 | |
| SCHEMBL6477298 | 0.76 | KDR (0.41) | KDRCCNCCDK8FLT1FLT4 | |
| Hydrochloric Acid SCHEMBL6478901 | 0.75 | KDR (0.49) | KDREGFRRETPDGFRBABL1 | |
| SCHEMBL1469755 | 0.74 | KDR (0.68) | KDRFLT1FLT4EGFRFGFR1 | |
| Hydrochloric Acid SCHEMBL1467375 | 0.74 | KDR (0.69) | KDRFLT1FLT4EGFRFGFR1 | |
| SCHEMBL6519234 | 0.73 | FLT1 (0.55) | KDRFLT1FLT4EGFRFGFR1 | |
| SCHEMBL6477340 | 0.72 | KDR (0.55) | KDRFLT1FLT4EGFRFGFR1 | |
| SCHEMBL4094159 | 0.71 | POLB (0.57) | CCNCCDK8POLBPDK2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6897210-B2 | Quinazoline derivatives and pharmaceutical compositions containing them | ZENECA LIMITED (GB) | 2005-05-24 | — | — | US | disclosed |