Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 12/20 | 0.55 |
| ▸ | FLT1 | P17948 | 10/20 | 0.55 |
| ▸ | FGFR1 | P11362 | 8/20 | 0.55 |
| ▸ | FLT4 | P35916 | 5/20 | 0.41 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.41 |
| ▸ | EGFR | P00533 | 5/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.36 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.35 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.35 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.35 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.35 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.35 |
| ▸ | IGF1R | P08069 | 1/20 | 0.35 |
| ▸ | SRC | P12931 | 1/20 | 0.35 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.35 |
| ▸ | TEK | Q02763 | 1/20 | 0.35 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1888746 | 0.87 | KDR (0.55) | KDRFLT1FGFR1FLT4EPHB2 | |
| SCHEMBL7736056 | 0.86 | KDR (0.67) | KDRFLT1FGFR1FLT4EPHB2 | |
| SCHEMBL6519234 | 0.85 | FLT1 (0.55) | KDRFLT1FGFR1FLT4EGFR | |
| Hydrochloric Acid SCHEMBL6896031 | 0.84 | KDR (0.52) | KDRFLT1FGFR1FLT4EPHB2 | |
| Hydrochloric Acid SCHEMBL6517806 | 0.82 | FLT1 (0.50) | KDRFLT1FGFR1FLT4EGFR | |
| SCHEMBL6529811 | 0.81 | HPGD (0.49) | KDRFLT1FGFR1FLT4EGFR | |
| Hydrochloric Acid SCHEMBL7460915 | 0.81 | KDR (0.49) | KDRFLT1FGFR1FLT4EPHB2 | |
| SCHEMBL7460547 | 0.79 | KDR (0.47) | KDRFLT1FGFR1FLT4EGFR | |
| SCHEMBL6486338 | 0.79 | USP2 (0.52) | KDRFLT1FGFR1FLT4EGFR | |
| SCHEMBL5462221 | 0.78 | KDR (0.44) | KDRFLT1FGFR1FLT4EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6897210-B2 | Quinazoline derivatives and pharmaceutical compositions containing them | ZENECA LIMITED (GB) | 2005-05-24 | — | — | US | disclosed |