Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | KDR | P35968 | 9/20 | 0.44 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.44 |
| ▸ | FLT1 | P17948 | 5/20 | 0.44 |
| ▸ | PDE3B | Q13370 | 2/20 | 0.44 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.44 |
| ▸ | PDE2A | O00408 | 1/20 | 0.44 |
| ▸ | P2RY12 | Q9H244 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 4/20 | 0.43 |
| ▸ | BRAF | P15056 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | FLT4 | P35916 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6529811 | 0.94 | HPGD (0.49) | USP2RAB9AKDRFGFR1FLT1 | |
| SCHEMBL6519234 | 0.81 | FLT1 (0.55) | KDRFGFR1FLT1EGFRFLT4 | |
| SCHEMBL6477340 | 0.79 | KDR (0.55) | KDRFGFR1FLT1EGFRFLT4 | |
| SCHEMBL1888746 | 0.78 | KDR (0.55) | KDRFGFR1FLT1EGFRFLT4 | |
| SCHEMBL6486350 | 0.77 | USP2 (0.50) | USP2RAB9AKDRFGFR1FLT1 | |
| Hydrochloric Acid SCHEMBL6896031 | 0.77 | KDR (0.52) | KDRFGFR1FLT1EGFRBRAF | |
| Hydrochloric Acid SCHEMBL6517806 | 0.77 | FLT1 (0.50) | KDRFGFR1FLT1EGFRFLT4 | |
| Hydrochloric Acid SCHEMBL6477886 | 0.76 | EGFR (0.53) | KDRFGFR1FLT1EGFRBRAF | |
| SCHEMBL7736056 | 0.76 | KDR (0.67) | KDRFGFR1FLT1EGFRFLT4 | |
| SCHEMBL1467152 | 0.74 | KDR (0.76) | KDRFGFR1FLT1EGFRFLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6897210-B2 | Quinazoline derivatives and pharmaceutical compositions containing them | ZENECA LIMITED (GB) | 2005-05-24 | — | — | US | disclosed |