Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.50 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.50 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.45 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.45 |
| ▸ | BLM | P54132 | 1/20 | 0.43 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2791174 | 1.00 | HDAC8 (0.56) | HDAC8KMT2AMEN1OPRM1OPRD1 | |
| SCHEMBL6930590 | 1.00 | HDAC8 (0.56) | HDAC8KMT2AMEN1OPRM1OPRD1 | |
| SCHEMBL29364300 | 1.00 | HDAC8 (0.56) | HDAC8KMT2AMEN1OPRM1OPRD1 | |
| Hydrochloric Acid SCHEMBL9595072 | 0.98 | HDAC8 (0.58) | HDAC8KMT2AMEN1OPRM1OPRD1 | |
| Hydrochloric Acid SCHEMBL7278121 | 0.98 | HDAC8 (0.58) | HDAC8KMT2AMEN1OPRM1OPRD1 | |
| SCHEMBL30839815 | 0.87 | KMT2A (0.52) | HDAC8KMT2AMEN1OPRM1OPRD1 | |
| SCHEMBL25523118 | 0.86 | KMT2A (0.51) | HDAC8KMT2AMEN1OPRM1OPRD1 | |
| SCHEMBL8268852 | 0.83 | KMT2A (0.56) | KMT2AMEN1OPRM1OPRD1OPRK1 | |
| SCHEMBL20812889 | 0.81 | HDAC8 (0.45) | HDAC8KMT2AMEN1OPRM1OPRD1 | |
| SCHEMBL27470508 | 0.81 | KMT2A (0.57) | HDAC8KMT2AMEN1OPRM1OPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 72 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118206487-A | Synthesis process of (S) -N-tert-butyl-1, 2,3, 4-tetrahydroisoquinoline-3-carboxamide | 四川什邡市三高生化实业有限公司 | 2024-06-18 | — | — | CN | claimed |
| US-6894167-B2 | Method of preparation of (s)-n-tert-butyl-1,2,3,4-tetrahydroisoquinoline-3-carboxamide | CLARIANT LIFE SCIENCE MOLECULES (ITALIA) S.P.A. (IT) | 2005-05-17 | — | — | US | claimed |
| EP-1104755-B1 | Process for the preparation of (S)-N-tertbutyl-1,2,3,4- tetrahydroisoquinoline-3-carboxamide | CLARIANT LSM ITALIA SPA (IT) | 2004-10-06 | — | — | EP | claimed |
| US-20040034056-A1 | Method of preparation of (s)-n-tert-butyl-1,2,3,4-tetrahydroisoquinoline-3-carboxamide | ARCHIMICA S.R.L. (IT) | 2004-02-19 | — | — | US | claimed |
| EP-0902781-B1 | PREPARATION OF (S)-DECAHYDROISOQUINOLINE-3-CARBOXYLIC ACID T-BUTYLAMIDE | PCBU SERVICES INC (US) | 2003-12-17 | — | — | EP | claimed |
| EP-1337514-A1 | METHOD OF PREPARATION OF (S)-N-TERT-BUTYL-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXAMIDE | Clariant Life Science Molecules (Italia) S.p.A. (IT) | 2003-08-27 | — | — | EP | claimed |
| EP-1140853-B1 | CONTINUOUS PROCESS FOR THE PREPARATION OF OPTICALLY PURE DECAHYDROISOQUINOLINECARBOXAMIDE | SK CORP (KR) | 2003-08-06 | — | — | EP | claimed |
| US-6586597-B1 | Reduction of N-tert-butyl-1,2,3,4-tetrahydro-3(S)-isoquinolinecarboxamide using hydrogenation catalyst on supports to form intermediates for antagonists of excitatory amino acid receptors or enzyme inhibitors; viral diseases | SK CORPORATION (KR) | 2003-07-01 | — | — | US | claimed |
| US-6433177-B1 | REACTING N-CARBOXYANHYDRIDE AND BUTYLAMINE | CLARIANT LSM ITALIA S.P.A. (IT) | 2002-08-13 | — | — | US | claimed |
| WO-2002030905-A1 | METHOD OF PREPARATION OF (S)-N-TERT-BUTYL-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXAMIDE | CLARIANT LIFE SCIENCE MOLECULES (ITALIA) S.P.A. (IT) | 2002-04-18 | — | — | WO | claimed |
| US-6340760-B1 | PRODUCING VIRAL DRUGS BY MULTISTAGE REACTION | CLARIANT LSM ITALIA S.P.A (IT) | 2002-01-22 | — | — | US | claimed |
| EP-1140853-A1 | CONTINUOUS PROCESS FOR THE PREPARATION OF OPTICALLY PURE DECAHYDROISOQUINOLINECARBOXAMIDE | SK Corporation (KR) | 2001-10-10 | — | — | EP | claimed |
| EP-1009749-B1 | PREPARATION OF (S)-N-TERT-BUTYL-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYAMIDE | CLARIANT LSM ITALIA SPA (IT) | 2001-08-08 | — | — | EP | claimed |
| EP-1104755-A1 | Process for the preparation of (S)-N-tertbutyl-1,2,3,4- tetrahydroisoquinoline-3-carboxamide | Clariant Life Science Molecules (Italia) S.p.a. (IT) | 2001-06-06 | — | — | EP | claimed |
| WO-2000035883-A1 | CONTINUOUS PROCESS FOR THE PREPARATION OF OPTICALLY PURE DECAHYDROISOQUINOLINECARBOXAMIDE | SK CORPORATION (KR) | 2000-06-22 | — | — | WO | claimed |
| EP-1009749-A1 | PREPARATION OF (S)-N-TERT-BUTYL-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYAMIDE | Archimica S.p.A. (IT) | 2000-06-21 | — | — | EP | claimed |
| WO-2000000494-A1 | PREPARATION OF (S)-N-TERT-BUTYL-1,2,3,4-TETRAHYDROISOQUINOLINE-3-CARBOXYAMIDE | ARCHIMICA S.P.A. (IT) | 2000-01-06 | — | — | WO | claimed |
| US-5587481-A | Preparation of (S)-decahydroisoquinoline-3-carboxylic acid t-butylamide | THE MONSANTO COMPANY (US) | 1996-12-24 | — | — | US | claimed |
| JP-5213887-A | — | — | None | — | — | JP | disclosed |
| EP-0533000-A1 | Process for the preparation of 3-substituted 1,2,3,4-tetrahydro isoquinoline derivatives | F.HOFFMANN-LA ROCHE & CO. AKTIENGESELLSCHAFT (CH) | 1993-03-24 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040034056-A1 | Method of preparation of (s)-n-tert-butyl-1,2,3,4-tetrahydroisoquinoline-3-carboxamide | CPS1, QTRT1, BET1 | HDAC8 2328/4885KMT2A 673/4885MEN1 955/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.