⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3748212 | 0.77 | — | — | |
| SCHEMBL4033787 | 0.77 | — | — | |
| SCHEMBL95098 | 0.75 | — | — | |
| SCHEMBL9349010 | 0.73 | — | — | |
| SCHEMBL8588526 | 0.73 | — | — | |
| SCHEMBL9346355 | 0.69 | ADH1B (0.31) | — | |
| SCHEMBL1721780 | 0.69 | — | — | |
| SCHEMBL11043534 | 0.69 | — | — | |
| SCHEMBL21518266 | 0.69 | CA1 (0.36) | — | |
| SCHEMBL1004291 | 0.69 | AKR1B1 (0.30) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 87 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10807970-B2 | Tetrahydropyran and thiopyran derivatives having multimodal activity against pain | ESTEVE PHARMACEUTICALS, S.A. (ES) | 2020-10-20 | — | — | US | disclosed |
| EP-3458450-B1 | TETRAHYDROPYRAN DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN | ESTEVE PHARMACEUTICALS SA (ES) | 2020-07-01 | — | — | EP | disclosed |
| US-20190241544-A1 | TETRAHYDROPYRAN AND THIOPYRAN DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN | ESTEVE PHARMACEUTICALS, S.A. (ES) | 2019-08-08 | — | — | US | disclosed |
| CN-109564213-A | Detecting microbial wound infection | 西诺福有限公司 | 2019-04-02 | — | — | CN | disclosed |
| EP-3458450-A1 | TETRAHYDROPYRAN AND THIOPYRAN DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN | ESTEVE PHARMACEUTICALS, S.A. (ES) | 2019-03-27 | — | — | EP | disclosed |
| CN-109153671-A | There is the active oxinane of multi-mode and thiapyran derivative for pain | 埃斯蒂文制药股份有限公司 | 2019-01-04 | — | — | CN | disclosed |
| WO-2018153546-A1 | TETRAHYDROPYRAN AND TETRAHYDROTHIOPYRAN METHANONE DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2018-08-30 | — | — | WO | disclosed |
| WO-2018153545-A1 | PIPERIDINE METHANONE DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2018-08-30 | — | — | WO | disclosed |
| WO-2017198339-A1 | TETRAHYDROPYRAN AND THIOPYRAN DERIVATIVES HAVING MULTIMODAL ACTIVITY AGAINST PAIN | LABORATORIOS DEL DR. ESTEVE, S.A. (ES) | 2017-11-23 | — | — | WO | disclosed |
| EP-1757609-B1 | NOVEL WATER-SOLUBLE PRODRUG | CHUGAI PHARMACEUTICAL CO LTD (JP) | 2013-10-16 | — | — | EP | disclosed |
| US-5001139-A | Enchancers for the transdermal flux of nivadipine | AMERICAN CYANAMID COMPANY (US) | 1991-03-19 | — | — | US | disclosed |
| US-4992445-A | Enantiomorphs of active chiral compounds in vehicle | AMERICAN CYANAMID CO. (US) | 1991-02-12 | — | — | US | disclosed |
| EP-0317780-A1 | Sustained (controlled) release delivery system for substituted dihydropyridine calcium channel blockers | AMERICAN CYANAMID COMPANY (US) | 1989-05-31 | — | — | EP | disclosed |
| US-4525478-A | Certain 4-aryl-1,4-dihydro-3,5-pyridinedicarboxylates having vasodilating and anti-hypertensive properties | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1985-06-25 | — | — | US | disclosed |
| US-4487781-A | HEAT RESISTANCE; PHOTOSTABILITY | SANKYO COMPANY LIMITED (JP) | 1984-12-11 | — | — | US | disclosed |
| US-4370334-A | VASODILATION | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1983-01-25 | — | — | US | disclosed |
| US-4338322-A | 1,4-Dihydropyridine derivatives, pharmaceutical compositions containing same and methods of effecting vasodilation using same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1982-07-06 | — | — | US | disclosed |
| US-4284634-A | HYPOTENSIVE VASODILATORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1981-08-18 | — | — | US | disclosed |
| US-4259350-A | PROTECTING DEGRADABLE ORGANIC MATERIAL FROM FUNGAL OR INSECT ATTACK | SANKYO COMPANY LIMITED (JP) | 1981-03-31 | — | — | US | disclosed |
| US-4145432-A | 6-ACYLORYALKYL-1,4-DIHYDROPYRIDINE DERIVATIVES AND A METHOD OF EFFECTING VASODILATION THEREWITH | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1979-03-20 | — | — | US | disclosed |