Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.58 |
| ▸ | EGFR | P00533 | 6/20 | 0.58 |
| ▸ | RET | P07949 | 2/20 | 0.58 |
| ▸ | KIF5B | P33176 | 2/20 | 0.58 |
| ▸ | GAK | O14976 | 4/20 | 0.54 |
| ▸ | FGFR1 | P11362 | 4/20 | 0.53 |
| ▸ | FLT1 | P17948 | 4/20 | 0.53 |
| ▸ | RAF1 | P04049 | 2/20 | 0.52 |
| ▸ | BRAF | P15056 | 2/20 | 0.52 |
| ▸ | EPHB6 | O15197 | 2/20 | 0.51 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.51 |
| ▸ | ABL1 | P00519 | 2/20 | 0.51 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.51 |
| ▸ | COQ8A | Q8NI60 | 2/20 | 0.51 |
| ▸ | NLK | Q9UBE8 | 2/20 | 0.51 |
| ▸ | STK16 | O75716 | 1/20 | 0.51 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.51 |
| ▸ | SRC | P12931 | 3/20 | 0.49 |
| ▸ | BRD4 | O60885 | 1/20 | 0.47 |
| ▸ | BRD2 | P25440 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1891633 | 0.86 | FLT1 (0.70) | KDREGFRGAKFGFR1FLT1 | |
| SCHEMBL27533397 | 0.86 | RAF1 (0.54) | KDREGFRGAKFGFR1FLT1 | |
| SCHEMBL156289 | 0.84 | KDR (0.83) | KDREGFRRETKIF5BGAK | |
| Hydrochloric Acid SCHEMBL28007000 | 0.83 | KDR (0.81) | KDREGFRRETKIF5BGAK | |
| SCHEMBL6436213 | 0.82 | FLT1 (0.70) | KDREGFRGAKFGFR1FLT1 | |
| SCHEMBL6433759 | 0.81 | FLT1 (0.65) | KDREGFRRETKIF5BGAK | |
| SCHEMBL5241456 | 0.80 | KDR (0.83) | KDREGFRRETKIF5BGAK | |
| Trifluoroacetic Acid SCHEMBL29372105 | 0.77 | KDR (0.70) | KDREGFRRETKIF5BGAK | |
| Trifluoroacetic Acid SCHEMBL2089050 | 0.77 | KDR (0.70) | KDREGFRRETKIF5BGAK | |
| SCHEMBL1781767 | 0.77 | KDR (0.71) | KDREGFRRETKIF5BGAK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6897210-B2 | Quinazoline derivatives and pharmaceutical compositions containing them | ZENECA LIMITED (GB) | 2005-05-24 | — | — | US | disclosed |