Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FLT1 | P17948 | 4/20 | 0.65 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.65 |
| ▸ | EGFR | P00533 | 6/20 | 0.55 |
| ▸ | GAK | O14976 | 3/20 | 0.55 |
| ▸ | KDR | P35968 | 7/20 | 0.54 |
| ▸ | SRC | P12931 | 3/20 | 0.54 |
| ▸ | RET | P07949 | 5/20 | 0.54 |
| ▸ | KIF5B | P33176 | 5/20 | 0.54 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.53 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.53 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.53 |
| ▸ | ABL1 | P00519 | 1/20 | 0.53 |
| ▸ | LCK | P06239 | 1/20 | 0.53 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.53 |
| ▸ | EPHA8 | P29322 | 1/20 | 0.53 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.53 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.53 |
| ▸ | COQ8A | Q8NI60 | 1/20 | 0.53 |
| ▸ | NLK | Q9UBE8 | 1/20 | 0.53 |
| ▸ | RAF1 | P04049 | 2/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8509837 | 0.89 | FLT1 (0.59) | FLT1FGFR1EGFRGAKKDR | |
| SCHEMBL6434776 | 0.89 | FLT1 (0.59) | FLT1FGFR1EGFRGAKKDR | |
| Hydrochloric Acid SCHEMBL6432639 | 0.88 | FLT1 (0.58) | FLT1FGFR1EGFRGAKKDR | |
| SCHEMBL6434212 | 0.87 | KDR (0.68) | FLT1FGFR1EGFRGAKKDR | |
| SCHEMBL6437903 | 0.86 | FLT1 (0.84) | FLT1FGFR1EGFRGAKKDR | |
| Hydrochloric Acid SCHEMBL6434300 | 0.86 | KDR (0.67) | FLT1FGFR1EGFRGAKKDR | |
| Hydrochloric Acid SCHEMBL6435465 | 0.85 | FLT1 (0.83) | FLT1FGFR1EGFRGAKKDR | |
| SCHEMBL27540175 | 0.81 | KDR (0.48) | FLT1FGFR1EGFRGAKKDR | |
| SCHEMBL5958960 | 0.81 | KDR (0.80) | FLT1FGFR1EGFRKDRRET | |
| SCHEMBL6046225 | 0.81 | EGFR (0.70) | FLT1FGFR1EGFRGAKKDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0929526-B1 | QINOLINE DERIVATIVES INHIBITING THE EFFECT OF GROWTH FACTORS SUCH AS VEGF | ASTRAZENECA AB (SE) | 2005-07-27 | — | — | EP | disclosed |
| US-6809097-B1 | ANTIANGIOGENIC AND/OR VASCULAR PERMEABILITY | ZENECA LIMITED (GB) | 2004-10-26 | — | — | US | disclosed |
| EP-0929526-A1 | QINOLINE DERIVATIVES INHIBITING THE EFFECT OF GROWTH FACTORS SUCH AS VEGF | ZENECA LIMITED (GB) | 1999-07-21 | — | — | EP | disclosed |
| WO-1998013350-A1 | QINOLINE DERIVATIVES INHIBITING THE EFFECT OF GROWTH FACTORS SUCH AS VEGF | ZENECA LIMITED (GB) | 1998-04-02 | — | — | WO | disclosed |