Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.41 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | CTPS1 | P17812 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 2/20 | 0.39 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.39 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.39 |
| ▸ | KDR | P35968 | 2/20 | 0.39 |
| ▸ | EPHB4 | P54760 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 5/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6487034 | 0.92 | SCN9A (0.45) | CYSLTR2CYSLTR1TP53EGFRERBB2 | |
| SCHEMBL6485303 | 0.90 | CYSLTR2 (0.45) | CYSLTR2CYSLTR1TP53EGFRERBB2 | |
| SCHEMBL6477804 | 0.88 | CYSLTR2 (0.42) | CYSLTR2CYSLTR1CTPS1EGFRERBB2 | |
| SCHEMBL6476503 | 0.87 | CYSLTR2 (0.48) | CYSLTR2CYSLTR1 | |
| SCHEMBL6526673 | 0.86 | EGFR (0.46) | CYSLTR2CYSLTR1TP53EGFRERBB2 | |
| SCHEMBL6484833 | 0.86 | CYSLTR2 (0.46) | CYSLTR2CYSLTR1CTPS1EGFRERBB2 | |
| SCHEMBL6486897 | 0.85 | MAPT (0.44) | CYSLTR2CYSLTR1TP53EGFRERBB2 | |
| SCHEMBL6475810 | 0.85 | CYSLTR2 (0.42) | CYSLTR2CYSLTR1TP53EGFRERBB2 | |
| SCHEMBL6485920 | 0.85 | SHMT2 (0.44) | CYSLTR2CYSLTR1TP53EGFRERBB2 | |
| SCHEMBL6485372 | 0.85 | CYSLTR2 (0.44) | CYSLTR2CYSLTR1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6933322-B2 | Substituted naphthylenes for the treatment of non-insulin dependent diabetes mellitus | WYETH (US) | 2005-08-23 | — | — | US | disclosed |