Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ENPP1 | P22413 | 3/20 | 0.54 |
| ▸ | EPHA2 | P29317 | 10/20 | 0.40 |
| ▸ | KDR | P35968 | 9/20 | 0.39 |
| ▸ | EPHB4 | P54760 | 5/20 | 0.39 |
| ▸ | EGFR | P00533 | 4/20 | 0.38 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.38 |
| ▸ | FLT1 | P17948 | 2/20 | 0.38 |
| ▸ | FLT4 | P35916 | 2/20 | 0.38 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.37 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.37 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.37 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4593476 | 0.81 | ENPP1 (0.59) | ENPP1EPHA2KDREPHB4EGFR | |
| SCHEMBL4590452 | 0.81 | ENPP1 (0.59) | ENPP1EPHA2KDREPHB4EGFR | |
| SCHEMBL15520006 | 0.78 | EPHA2 (0.58) | ENPP1EPHA2KDREPHB4 | |
| SCHEMBL30864338 | 0.74 | ENPP1 (0.79) | ENPP1KDREGFRFGFR1FLT1 | |
| SCHEMBL1013021 | 0.74 | ENPP1 (0.79) | ENPP1EPHA2KDREPHB4EGFR | |
| SCHEMBL1013051 | 0.74 | ENPP1 (0.79) | ENPP1KDREGFRFGFR1FLT1 | |
| SCHEMBL1015576 | 0.74 | ENPP1 (0.79) | ENPP1KDREGFRFGFR1FLT1 | |
| SCHEMBL662795 | 0.74 | ENPP1 (0.79) | ENPP1EPHA2KDREPHB4EGFR | |
| SCHEMBL31620798 | 0.74 | ENPP1 (0.79) | ENPP1KDREGFRFGFR1FLT1 | |
| SCHEMBL1012358 | 0.74 | ENPP1 (0.79) | ENPP1EPHA2KDREPHB4EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6939866-B2 | Quinazoline derivatives | ASTRAZENECA AB (SE) | 2005-09-06 | — | — | US | disclosed |
| US-20040044015-A1 | Quinazoline derivatives | ASTRAZENECA AB (SE) | 2004-03-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040044015-A1 | Quinazoline derivatives | NQO2, NRAS, TOP1 | ENPP1 3445/4885EPHA2 3735/4885KDR 2216/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.