Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | NFE2L2 | Q16236 | 4/20 | 0.50 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | MAPT | P10636 | 3/20 | 0.50 |
| ▸ | PKM | P14618 | 1/20 | 0.50 |
| ▸ | PLIN1 | O60240 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | PLIN5 | Q00G26 | 1/20 | 0.50 |
| ▸ | ABHD5 | Q8WTS1 | 1/20 | 0.50 |
| ▸ | TFEB | P19484 | 1/20 | 0.50 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.48 |
| ▸ | TLR2 | O60603 | 1/20 | 0.47 |
| ▸ | ERN1 | O75460 | 1/20 | 0.47 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.47 |
| ▸ | TLR6 | Q9Y2C9 | 1/20 | 0.47 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2046280 | 0.83 | KDM4E (0.56) | KDM4EKMT2AMEN1ALDH1A1CYP3A4 | |
| SCHEMBL13891035 | 0.80 | GRIN2D (0.54) | KDM4EKMT2AMEN1ALDH1A1CYP3A4 | |
| SCHEMBL2052380 | 0.78 | NFE2L2 (0.53) | KDM4EKMT2AMEN1ALDH1A1CYP3A4 | |
| SCHEMBL10515793 | 0.78 | NFE2L2 (0.52) | KDM4EKMT2AMEN1ALDH1A1CYP3A4 | |
| SCHEMBL30804567 | 0.78 | NFE2L2 (0.53) | KDM4EKMT2AMEN1ALDH1A1CYP3A4 | |
| SCHEMBL16933853 | 0.78 | NFE2L2 (0.52) | KDM4EKMT2AMEN1ALDH1A1CYP3A4 | |
| SCHEMBL26608681 | 0.78 | GRIN2D (0.56) | KDM4EKMT2AMEN1ALDH1A1NFE2L2 | |
| SCHEMBL3303048 | 0.77 | KDM4E (0.54) | KDM4EKMT2AMEN1ALDH1A1CYP3A4 | |
| SCHEMBL10533217 | 0.77 | KDM4E (0.54) | KDM4EKMT2AMEN1ALDH1A1CYP3A4 | |
| SCHEMBL11763787 | 0.77 | KDM4E (0.59) | KDM4EKMT2AMEN1NFE2L2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005007162-A1 | COMPOUNDS AUGMENTING THE ACTIVITY OF ANTIBACTERIAL AGENTS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2005-01-27 | — | — | WO | claimed |