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Tryptophan

Tryptophan

SCHEMBL6479239

CC(C)C[C@H](N)C(=O)O.CC(C)[C@H](N)C(=O)O.CC[C@H](C)[C@H](N)C(=O)O.CSCC[C@H](N)C(=O)O.C[C@@H](O)[C@H](N)C(=O)O.NC(=O)CC[C@H](N)C(=O)O.NC(=O)C[C@H](N)C(=O)O.NCC(=O)O.NCCCC[C@H](N)C(=O)O.N[C@@H](CC(=O)O)C(=O)O.N[C@@H](CCC(=O)O)C(=O)O.N[C@@H](CO)C(=O)O.N[C@@H](CS)C(=O)O.N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O.N[C@@H](Cc1c[nH]cn1)C(=O)O.N[C@@H](Cc1ccc(O)cc1)C(=O)O.N[C@@H](Cc1ccccc1)C(=O)O.O=C(O)[C@@H]1CCCN1

nearest known ligand 0.43

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA

The experimentally established mechanism targets of Tryptophan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ GLP1R P43220 15/20 0.41
▸ CCKBR P32239 4/20 0.40
▸ CALCR P30988 3/20 0.40
▸ CRHR1 P34998 1/20 0.40
▸ CRHR2 Q13324 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tryptophan SCHEMBL6437399 0.98 GLP1R (0.41) GLP1RCCKBRCALCR
Tryptophan SCHEMBL27646591 0.96 GLP1R (0.45) GLP1RCCKBR
Tryptophan SCHEMBL6563945 0.96 GLP1R (0.41) GLP1R
Tryptophan SCHEMBL27448344 0.96 GLP1R (0.44) GLP1RCCKBR
Tryptophan SCHEMBL27645885 0.96 GLP1R (0.44) GLP1RCCKBR
Tryptophan SCHEMBL6438435 0.95 GLP1R (0.40) GLP1R
Tryptophan SCHEMBL27700472 0.95 GLP1R (0.45) GLP1RCCKBR
Tryptophan SCHEMBL27505901 0.95 GLP1R (0.45) GLP1RCCKBR
Tryptophan SCHEMBL28943517 0.95 PTH1R (0.38) GLP1RCCKBRCALCR
Tryptophan SCHEMBL27568514 0.94 GLP1R (0.43) GLP1RCCKBR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1562578-A1 THERAPEUTIC DELIVERY OF CARBON MONOXIDE TO EXTRACORPOREAL AND ISOLATED ORGANS Hemocorm Limited (GB) 2005-08-17 — — EP claimed
WO-2004045598-A1 THERAPEUTIC DELIVERY OF CARBON MONOXIDE TO EXTRACORPOREAL AND ISOLATED ORGANS HEMOCORM LIMITED (GB) 2004-06-03 — — WO claimed