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Tryptophan

Tryptophan

SCHEMBL6563945

CC(C)C[C@H](N)C(=O)O.CC(C)[C@H](N)C(=O)O.CC[C@H](C)[C@H](N)C(=O)O.CSCC[C@H](N)C(=O)O.C[C@@H](O)[C@H](N)C(=O)O.NC(=O)CC[C@H](N)C(=O)O.NCC(=O)O.NCCCC[C@H](N)C(=O)O.N[C@@H](CCC(=O)O)C(=O)O.N[C@@H](CO)C(=O)O.N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O.N[C@@H](Cc1c[nH]cn1)C(=O)O.N[C@@H](Cc1ccc(O)cc1)C(=O)O.N[C@@H](Cc1ccccc1)C(=O)O.O=C(O)[C@@H]1CCCN1

nearest known ligand 0.41

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Known targets — ChEMBL curated mechanism

PPARDPTGS1PTGS2dacAdacBdacCftsImrcAmrcBmrdA

The experimentally established mechanism targets of Tryptophan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
▸ GLP1R P43220 19/20 0.41
▸ GCGR P47871 3/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Tryptophan SCHEMBL6438435 0.99 GLP1R (0.40) GLP1RGCGR
Tryptophan SCHEMBL6437399 0.98 GLP1R (0.41) GLP1R
Tryptophan SCHEMBL6479239 0.96 GLP1R (0.41) GLP1R
Tryptophan SCHEMBL27668300 0.95 GLP1R (0.46) GLP1RGCGR
Tryptophan SCHEMBL28943517 0.94 PTH1R (0.38) GLP1R
Tyrosine SCHEMBL9538046 0.94 CRHR1 (0.40) GLP1R
Tryptophan SCHEMBL27651679 0.94 GHSR (0.38) GLP1RGCGR
Tryptophan SCHEMBL27527055 0.94 GLP1R (0.45) GLP1RGCGR
Tryptophan SCHEMBL27505901 0.93 GLP1R (0.45) GLP1RGCGR
Tryptophan SCHEMBL27700472 0.93 GLP1R (0.45) GLP1RGCGR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1399147-A2 THERAPEUTIC DELIVERY OF CARBON MONOXIDE Northwick Park Institute For Medical Research (GB) 2004-03-24 — — EP claimed
WO-2002092075-A2 THERAPEUTIC DELIVERY OF CARBON MONOXIDE NORTHWICK PARK INSTITUTE FOR MEDICAL RESEARCH (GB) 2002-11-21 — — WO claimed