Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | ANPEP | P15144 | 1/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.34 |
| ▸ | CETP | P11597 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | KLK7 | P49862 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.33 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.32 |
| ▸ | TPSD1 | Q9BZJ3 | 1/20 | 0.32 |
| ▸ | TPSG1 | Q9NRR2 | 1/20 | 0.32 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.32 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12686993 | 1.00 | PTPN1 (0.35) | PTPN1NR1H2BRD4MMP2ANPEP | |
| SCHEMBL19566179 | 0.92 | NR1H2 (0.35) | NR1H2CHRM2CHRM1CHRM3KLK7 | |
| SCHEMBL6494880 | 0.86 | KLK7 (0.36) | NR1H2CHRM2CHRM1CHRM3KLK7 | |
| SCHEMBL15659293 | 0.86 | NR1H2 (0.37) | PTPN1NR1H2MMP2ANPEPNR1H3 | |
| SCHEMBL15659291 | 0.86 | NR1H2 (0.37) | PTPN1NR1H2MMP2ANPEPNR1H3 | |
| SCHEMBL18256386 | 0.86 | NR1H2 (0.37) | PTPN1NR1H2MMP2ANPEPNR1H3 | |
| SCHEMBL25842893 | 0.86 | PTPN1 (0.34) | PTPN1NR1H2MMP2ANPEPNR1H3 | |
| Hydrochloric Acid SCHEMBL30661150 | 0.85 | PTPN1 (0.33) | PTPN1NR1H2MMP2ANPEPNR1H3 | |
| SCHEMBL6184927 | 0.85 | FAAH (0.34) | PTPN1NR1H2MMP2ANPEPNR1H3 | |
| SCHEMBL15700777 | 0.85 | FAAH (0.34) | PTPN1NR1H2MMP2ANPEPNR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050038030-A1 | Amino-bicyclic pyrazinones and pyridinones as coagulation serine protease inhibitors | BRISTOL-MYERS SQUIBB COMPANY | 2005-02-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050038030-A1 | Amino-bicyclic pyrazinones and pyridinones as coagulation serine protease inhibitors | TFPI, F5, F2 | PTPN1 2175/4885NR1H2 4574/4885BRD4 1335/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.