Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 1/20 | 0.61 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | CTSL | P07711 | 1/20 | 0.37 |
| ▸ | F2R | P25116 | 4/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.35 |
| ▸ | UBE2M | P61081 | 1/20 | 0.35 |
| ▸ | DCUN1D1 | Q96GG9 | 1/20 | 0.35 |
| ▸ | CXCR3 | P49682 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1912909 | 1.00 | C5AR1 (0.61) | C5AR1SMN1; SMN2LMNAL3MBTL1CTSL | |
| SCHEMBL1912894 | 0.91 | C5AR1 (0.59) | C5AR1SMN1; SMN2LMNAL3MBTL1CTSL | |
| SCHEMBL648933 | 0.91 | C5AR1 (0.59) | C5AR1SMN1; SMN2LMNAL3MBTL1CTSL | |
| SCHEMBL651831 | 0.90 | C5AR1 (0.71) | C5AR1SMN1; SMN2LMNAL3MBTL1F2R | |
| SCHEMBL650902 | 0.90 | C5AR1 (0.71) | C5AR1SMN1; SMN2LMNAL3MBTL1F2R | |
| SCHEMBL648056 | 0.89 | C5AR1 (0.47) | C5AR1CXCR3 | |
| SCHEMBL649760 | 0.89 | C5AR1 (0.47) | C5AR1CXCR3 | |
| SCHEMBL4770465 | 0.89 | C5AR1 (0.69) | C5AR1SMN1; SMN2LMNAL3MBTL1F2R | |
| SCHEMBL651497 | 0.88 | C5AR1 (0.68) | C5AR1SMN1; SMN2LMNAL3MBTL1F2R | |
| SCHEMBL650905 | 0.88 | C5AR1 (0.68) | C5AR1SMN1; SMN2LMNAL3MBTL1F2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |
| EP-1490343-A1 | NEW ARYL IMIDAZOLES AND RELATED COMPOUNDS AS C5A RECEPTOR MODULATORS | Neurogen Corporation (US) | 2004-12-29 | — | — | EP | disclosed |
| WO-2003082829-A1 | NEW ARYL IMIDAZOLES AND RELATED COMPOUNDS AS C5A RECEPTOR MODULATORS | NEUROGEN CORPORATION (US) | 2003-10-09 | — | — | WO | disclosed |