Tryptophan

SCHEMBL6480796

CC(C)[C@H](N)C(=O)O.CSCC[C@H](N)C(=O)O.C[C@@H](O)[C@H](N)C(=O)O.N[C@@H](CO)C(=O)O.N[C@@H](Cc1c[nH]c2ccccc12)C(=O)O.N[C@@H](Cc1ccc(O)cc1)C(=O)O.N[C@@H](Cc1ccccc1)C(=O)O.O=C(O)[C@@H]1CCCN1

nearest known ligand 0.41

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

SLC5A2

The experimentally established mechanism targets of Tryptophan. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 14)

	gene	UniProt	supporting neighbours	confidence
▸	MEN1	O00255	2/20	0.41

▸	KMT2A	Q03164	2/20	0.41

▸	KDM4E	B2RXH2	1/20	0.41

▸	LMNA	P02545	1/20	0.41

▸	MPO	P05164	1/20	0.41

▸	MAPT	P10636	1/20	0.41

▸	TSHR	P16473	1/20	0.41

▸	BLM	P54132	1/20	0.41

▸	PMP22	Q01453	1/20	0.41

▸	HIF1A	Q16665	1/20	0.41

▸	CCKBR	P32239	2/20	0.40

▸	OPRM1	P35372	2/20	0.40

▸	OPRD1	P41143	2/20	0.40

▸	CTSC	P53634	1/20	0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
Tryptophan SCHEMBL9668365	0.98	MEN1 (0.43)	MEN1KMT2AKDM4ELMNAMPO
Tryptophan SCHEMBL28755030	0.93	GHSR (0.42)	MEN1KMT2ACCKBR
Dl-Tryptophan SCHEMBL28940888	0.92	MEN1 (0.43)	MEN1KMT2AKDM4ELMNAMPO
Dl-Tryptophan SCHEMBL27657599	0.92	KDM4E (0.48)	MEN1KMT2AKDM4ELMNAMPO
Dl-Tryptophan SCHEMBL28940322	0.92	MEN1 (0.43)	MEN1KMT2AKDM4ELMNAMPO
Tryptophan SCHEMBL28940321	0.92	MEN1 (0.43)	MEN1KMT2AKDM4ELMNAMPO
Tryptophan SCHEMBL27620479	0.91	GHSR (0.44)	MEN1KMT2ACCKBR
Tryptophan SCHEMBL6437302	0.90	GHSR (0.41)	MEN1KMT2ACCKBR
Dl-Tryptophan SCHEMBL28018820	0.90	KDM4E (0.43)	MEN1KMT2AKDM4ELMNAMPO
Tryptophan SCHEMBL27561253	0.90	KDM4E (0.47)	MEN1KMT2AKDM4ELMNAMPO

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
EP-1562578-A1	THERAPEUTIC DELIVERY OF CARBON MONOXIDE TO EXTRACORPOREAL AND ISOLATED ORGANS	Hemocorm Limited (GB)	2005-08-17	—	—	EP	claimed
WO-2004045598-A1	THERAPEUTIC DELIVERY OF CARBON MONOXIDE TO EXTRACORPOREAL AND ISOLATED ORGANS	HEMOCORM LIMITED (GB)	2004-06-03	—	—	WO	claimed