Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA4 | P48058 | 14/20 | 0.49 |
| ▸ | PPARG | P37231 | 1/20 | 0.46 |
| ▸ | PPARA | Q07869 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA9 | Q16790 | 1/20 | 0.41 |
| ▸ | MTNR1A | P48039 | 2/20 | 0.39 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.39 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.37 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.37 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6480965 | 0.86 | GRIA4 (0.48) | GRIA4MTNR1AMTNR1BGRIA1GRIA2 | |
| SCHEMBL6473885 | 0.86 | GRIA4 (0.67) | GRIA4PPARGPPARAMTNR1AMTNR1B | |
| SCHEMBL6475291 | 0.85 | GRIA4 (0.62) | GRIA4MTNR1AMTNR1BGRIA1GRIA2 | |
| SCHEMBL6482318 | 0.85 | GRIA4 (0.53) | GRIA4MTNR1AMTNR1BGRIA1GRIA2 | |
| SCHEMBL6480940 | 0.84 | GRIA4 (0.52) | GRIA4PPARGPPARACA12CA1 | |
| SCHEMBL6481760 | 0.84 | GRIA4 (0.46) | GRIA4PPARGPPARAMTNR1AMTNR1B | |
| SCHEMBL6480921 | 0.83 | PPARG (0.48) | GRIA4PPARGPPARAMTNR1AMTNR1B | |
| SCHEMBL6474389 | 0.82 | GRIA4 (0.62) | GRIA4PPARGPPARAMTNR1AMTNR1B | |
| SCHEMBL5877884 | 0.80 | GRIA4 (0.74) | GRIA4GRIA1GRIA2GRIA3 | |
| SCHEMBL6482156 | 0.80 | MTNR1A (0.52) | GRIA4MTNR1AMTNR1BGRIA1GRIA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030225266-A1 | Sulfonamide derivatives | ELI LILLY AND COMPANY | 2003-12-04 | — | — | US | claimed |
| EP-1265857-A1 | SULFONAMIDE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2002-12-18 | — | — | EP | claimed |
| WO-2001068592-A1 | SULFONAMIDE DERIVATIVES | ELI LILLY AND COMPANY (US) | 2001-09-20 | — | — | WO | claimed |
| US-6911476-B2 | Sulfonamide derivatives | ELI LILLY AND COMPANY (US) | 2005-06-28 | — | — | US | disclosed |
| US-20030225266-A1 | Sulfonamide derivatives | ELI LILLY AND COMPANY | 2003-12-04 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030225266-A1 | Sulfonamide derivatives | GRIN2A, GRM2, GRIA2 | GRIA4 6/4885PPARG 828/4885PPARA 1066/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.