Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.51 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.51 |
| ▸ | FYN | P06241 | 3/20 | 0.46 |
| ▸ | AURKA | O14965 | 5/20 | 0.46 |
| ▸ | CCNA2 | P20248 | 5/20 | 0.46 |
| ▸ | CDK2 | P24941 | 5/20 | 0.46 |
| ▸ | TTK | P33981 | 5/20 | 0.46 |
| ▸ | NAMPT | P43490 | 1/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | MMP13 | P45452 | 2/20 | 0.43 |
| ▸ | ITK | Q08881 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HPGD | P15428 | 1/20 | 0.42 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.41 |
| ▸ | CLK2 | P49760 | 1/20 | 0.41 |
| ▸ | CLK3 | P49761 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5755889 | 0.92 | PDE10A (0.50) | PDE10AKCNQ2FYNAURKACCNA2 | |
| SCHEMBL5815787 | 0.91 | KCNQ2 (0.49) | PDE10AKCNQ2FYNAURKACCNA2 | |
| SCHEMBL5756127 | 0.84 | TNIK (0.50) | KCNQ2FYNAURKACCNA2CDK2 | |
| SCHEMBL5814937 | 0.84 | ROCK2 (0.52) | AURKANAMPTMEN1KMT2AKDM4E | |
| SCHEMBL5755746 | 0.84 | NAMPT (0.51) | KCNQ2FYNAURKACCNA2CDK2 | |
| SCHEMBL5754846 | 0.83 | ROCK2 (0.47) | KCNQ2FYNAURKACCNA2CDK2 | |
| SCHEMBL6480489 | 0.83 | ITK (0.46) | PDE10AFYNAURKACCNA2CDK2 | |
| SCHEMBL5760150 | 0.81 | ROCK2 (0.64) | FYNNAMPTITKROCK2ROCK1 | |
| SCHEMBL5820065 | 0.80 | NPC1 (0.59) | NAMPTMEN1KMT2AMMP13ITK | |
| SCHEMBL5754607 | 0.78 | NAMPT (0.71) | NAMPTITKROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050032869-A1 | Pyrazolyl-indole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | PHARMACIA ITALIA S.P.A. (IT) | 2005-02-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050032869-A1 | Pyrazolyl-indole derivatives active as kinase inhibitors, process for their preparation and pharmaceutical compositions comprising them | MAP3K9, MAP3K20, MAP3K19 | PDE10A 885/4885KCNQ2 1417/4885FYN 223/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.