Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 8/20 | 0.88 |
| ▸ | RAB9A | P51151 | 8/20 | 0.88 |
| ▸ | MAPT | P10636 | 8/20 | 0.88 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.88 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.88 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.81 |
| ▸ | PPARG | P37231 | 2/20 | 0.76 |
| ▸ | NCOA2 | Q15596 | 2/20 | 0.76 |
| ▸ | NCOA1 | Q15788 | 2/20 | 0.76 |
| ▸ | NCOA3 | Q9Y6Q9 | 2/20 | 0.76 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.76 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.76 |
| ▸ | RELA | Q04206 | 1/20 | 0.76 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.59 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12788381 | 0.93 | NPC1 (1.00) | NPC1RAB9AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL6482978 | 0.89 | NPC1 (0.80) | NPC1RAB9AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL27768717 | 0.88 | NPC1 (0.83) | NPC1RAB9AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL1222603 | 0.81 | ALDH1A1 (0.72) | NPC1RAB9AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL3100772 | 0.78 | HDAC6 (0.94) | NPC1RAB9AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL892779 | 0.78 | MAPT (0.68) | NPC1RAB9AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL850828 | 0.78 | NPC1 (0.68) | NPC1RAB9AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL724552 | 0.77 | NPC1 (0.64) | NPC1RAB9AMAPTALDH1A1SMN1; SMN2 | |
| SCHEMBL14814460 | 0.76 | SMN1; SMN2 (0.61) | NPC1RAB9AMAPTALDH1A1SMN1; SMN2 | |
| Methylsulfanylmethane SCHEMBL28241748 | 0.75 | SMN1; SMN2 (0.64) | NPC1RAB9AMAPTALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6869967-B2 | Peroxisome proliferator-activated receptor (PPAR) active vinyl carboxylic acid derivatives | NOVO NORDISK A/S (DK) | 2005-03-22 | — | — | US | disclosed |
| EP-1414778-A1 | NOVEL VINYL CARBOXYLIC ACID DERIVATIVES AND THEIR USE AS ANTIDIABETICS ETC. | NOVO NORDISK A/S (DK) | 2004-05-06 | — | — | EP | disclosed |
| US-20030139473-A1 | Novel compounds, their preparation and use | VTVX HOLDINGS II LLC | 2003-07-24 | — | — | US | disclosed |
| WO-2003011807-A1 | NOVEL VINYL CARBOXYLIC ACID DERIVATIVES AND THEIR USE AS ANTIDIABETICS ETC. | NOVO NORDISK A/S (DK) | 2003-02-13 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030139473-A1 | Novel compounds, their preparation and use | PPARG, PPARD, PPARA | NPC1 546/4885RAB9A 2668/4885MAPT 3939/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.