Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 1/20 | 0.46 |
| ▸ | LIPG | Q9Y5X9 | 5/20 | 0.43 |
| ▸ | LPL | P06858 | 4/20 | 0.43 |
| ▸ | F2 | P00734 | 2/20 | 0.41 |
| ▸ | F11 | P03951 | 2/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.41 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.41 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.41 |
| ▸ | P4HB | P07237 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 3/20 | 0.38 |
| ▸ | CA2 | P00918 | 3/20 | 0.38 |
| ▸ | CA9 | Q16790 | 3/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.38 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.37 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28929431 | 0.87 | ROCK1 (0.45) | ROCK1LIPGLPLF2F11 | |
| SCHEMBL6183441 | 0.84 | ROCK1 (0.45) | ROCK1LIPGLPLF2F11 | |
| SCHEMBL25177249 | 0.82 | AAK1 (0.45) | ROCK1LIPGLPLF2F11 | |
| SCHEMBL31264705 | 0.81 | ROCK1 (0.47) | ROCK1LIPGLPLBACE1BACE2 | |
| SCHEMBL31264645 | 0.81 | ROCK1 (0.47) | ROCK1LIPGLPLBACE1BACE2 | |
| SCHEMBL1643648 | 0.81 | HIF1A (0.41) | LIPGLPLF2F11PRSS1 | |
| SCHEMBL142144 | 0.80 | LPL (0.49) | ROCK1LIPGLPLCA1CA2 | |
| SCHEMBL31264766 | 0.80 | ROCK1 (0.47) | ROCK1LMNAMAPK1HTTRAB9A | |
| SCHEMBL1130871 | 0.78 | ROCK1 (0.48) | ROCK1LIPGLPLF2F11 | |
| SCHEMBL4366318 | 0.77 | LPL (0.47) | ROCK1LIPGLPLP4HBCA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6919343-B2 | N-biphenyl(substituted methyl) aminocycloalkane-carboxamide derivatives | MERCK & CO., INC. (US) | 2005-07-19 | — | — | US | disclosed |