Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | PGR | P06401 | 1/20 | 0.42 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.38 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7217647 | 0.78 | ALDH1A1 (0.44) | ALDH1A1HPGDMAPTPGRADRA2A | |
| SCHEMBL12984511 | 0.78 | ALDH1A1 (0.44) | ALDH1A1HPGDMAPTPGRADRA2A | |
| SCHEMBL1004615 | 0.78 | NAMPT (0.55) | ALDH1A1HPGDMAPTPGRADRA2A | |
| SCHEMBL12984130 | 0.75 | ALDH1A1 (0.47) | ALDH1A1HPGDMAPTPGRADRA2A | |
| SCHEMBL12984476 | 0.74 | ALDH1A1 (0.43) | ALDH1A1HPGDMAPTPGRADRA2A | |
| SCHEMBL12984203 | 0.74 | KMT2A (0.45) | ALDH1A1HPGDMAPTPGRADRA2A | |
| SCHEMBL12983984 | 0.73 | KMT2A (0.44) | ALDH1A1HPGDMAPTPGRADRA2A | |
| SCHEMBL28214961 | 0.72 | HPGD (0.47) | ALDH1A1HPGDMAPTPGRADRA2A | |
| SCHEMBL29172976 | 0.71 | ALDH1A1 (0.46) | ALDH1A1HPGDMAPTPGRADRA2A | |
| SCHEMBL12984116 | 0.71 | MEN1 (0.48) | ALDH1A1HPGDMAPTPGRADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6953779-B2 | Melanocortin receptor antagonists and modulations of melanocortin receptor activity | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2005-10-11 | — | — | US | disclosed |
| US-20020004485-A1 | Melanocortin receptor antagonists and modulations of melanocortin receptor activity | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA | 2002-01-10 | — | — | US | disclosed |
| US-6228840-B1 | ADMINISTERING N-ANISOYLATED HEPTAPEPTIDE TO INHIBIT MELANOCYTE STIMULATING HORMONE; TREATING MELANOMAS | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT | 2001-05-08 | — | — | US | disclosed |
| WO-1999043709-A2 | MELANOCORTIN RECEPTOR ANTAGONISTS AND MODULATIONS OF MELANOCORTIN RECEPTOR ACTIVITY | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1999-09-02 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020004485-A1 | Melanocortin receptor antagonists and modulations of melanocortin receptor activity | MC3R, MC1R, MC5R | ALDH1A1 3482/4885HPGD 2566/4885MAPT 3355/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.