Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.40 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.39 |
| ▸ | F2R | P25116 | 8/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | ESR1 | P03372 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL650618 | 0.95 | ALDH1A1 (0.41) | ALDH1A1MAPK1OPRM1OPRD1C5AR1 | |
| SCHEMBL649494 | 0.91 | C5AR1 (0.44) | ALDH1A1MAPK1OPRM1OPRD1C5AR1 | |
| SCHEMBL648633 | 0.89 | C5AR1 (0.50) | ALDH1A1MAPK1OPRM1OPRD1C5AR1 | |
| SCHEMBL650106 | 0.87 | C5AR1 (0.40) | ALDH1A1MAPK1OPRM1OPRD1C5AR1 | |
| SCHEMBL650054 | 0.86 | C5AR1 (0.49) | C5AR1TSHRGAAKDM4E | |
| SCHEMBL1913026 | 0.85 | C5AR1 (0.56) | C5AR1TSHR | |
| SCHEMBL648110 | 0.84 | C5AR1 (0.49) | ALDH1A1MAPK1OPRM1OPRD1C5AR1 | |
| SCHEMBL649431 | 0.84 | C5AR1 (0.44) | ALDH1A1MAPK1OPRM1OPRD1C5AR1 | |
| SCHEMBL650039 | 0.83 | C5AR1 (0.49) | ALDH1A1MAPK1OPRM1OPRD1C5AR1 | |
| SCHEMBL1913083 | 0.83 | C5AR1 (0.43) | ALDH1A1MAPK1OPRM1OPRD1C5AR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |