Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 13/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TLR7 | Q9NYK1 | 4/20 | 0.37 |
| ▸ | AGTR2 | P50052 | 3/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL647754 | 0.92 | SMN1; SMN2 (0.41) | CNR1CNR2SMN1; SMN2 | |
| SCHEMBL653426 | 0.84 | C5AR1 (0.38) | AGTR1LMNATLR7SMN1; SMN2 | |
| SCHEMBL14572909 | 0.84 | SMN1; SMN2 (0.43) | CNR1CNR2SMN1; SMN2 | |
| SCHEMBL651244 | 0.83 | C5AR1 (0.44) | LMNASMN1; SMN2 | |
| SCHEMBL652511 | 0.83 | C5AR1 (0.39) | LMNASMN1; SMN2 | |
| SCHEMBL649715 | 0.83 | MEN1 (0.33) | SMN1; SMN2 | |
| SCHEMBL648054 | 0.81 | NR1H2 (0.39) | AGTR1TLR7SMN1; SMN2 | |
| SCHEMBL650281 | 0.80 | AGTR1 (0.40) | AGTR1TLR7AGTR2 | |
| SCHEMBL648072 | 0.78 | AGTR1 (0.39) | AGTR1TLR7 | |
| SCHEMBL651294 | 0.77 | BCHE (0.40) | TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |