SCHEMBL6484573

SCHEMBL6484573

CC(C)(C)NC(=O)CN1CC[N]CC1

nearest known ligand 0.55

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.55
SMN1; SMN2 Q16637 6/20 0.51
CACNA1H O95180 3/20 0.51
KMT2A Q03164 3/20 0.46
CACNA1I Q9P0X4 2/20 0.42
LMNA P02545 3/20 0.41
GAA P10253 4/20 0.40
KDM4E B2RXH2 1/20 0.40
MAPT P10636 1/20 0.40
GFER P55789 1/20 0.40
NPC1 O15118 1/20 0.40
SIGMAR1 Q99720 1/20 0.39
MEN1 O00255 2/20 0.39
HTT P42858 2/20 0.39
USP2 O75604 1/20 0.39
CACNA1G O43497 1/20 0.38
PKM P14618 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10101745 0.82 ALDH1A1 (0.71) ALDH1A1SMN1; SMN2CACNA1HKMT2ACACNA1I
SCHEMBL18743780 0.82 ALDH1A1 (0.66) ALDH1A1SMN1; SMN2CACNA1HKMT2ACACNA1I
SCHEMBL12454178 0.81 ALDH1A1 (0.74) ALDH1A1SMN1; SMN2CACNA1HKMT2ACACNA1I
SCHEMBL24926262 0.81 ALDH1A1 (0.74) ALDH1A1SMN1; SMN2CACNA1HKMT2ACACNA1I
SCHEMBL24926282 0.81 ALDH1A1 (0.74) ALDH1A1SMN1; SMN2CACNA1HKMT2ACACNA1I
SCHEMBL22403854 0.79 ALDH1A1 (0.61) ALDH1A1SMN1; SMN2CACNA1HKMT2ACACNA1I
SCHEMBL11930700 0.79 ALDH1A1 (0.61) ALDH1A1SMN1; SMN2CACNA1HKMT2ACACNA1I
SCHEMBL19248414 0.79 ALDH1A1 (0.61) ALDH1A1SMN1; SMN2CACNA1HKMT2ACACNA1I
SCHEMBL8248140 0.79 ALDH1A1 (0.61) ALDH1A1SMN1; SMN2CACNA1HKMT2ALMNA
SCHEMBL19079021 0.79 ALDH1A1 (0.61) ALDH1A1SMN1; SMN2CACNA1HKMT2ACACNA1I

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6962911-B2 Pyrrolopyrimidinone derivatives, process of preparation and use SK CHEMICALS CO., LTD. (KR) 2005-11-08 US disclosed
EP-1257553-B1 PYRROLOPYRIMIDINONE DERIVATIVES, PROCESS OF PREPARATION AND USE SK CHEMICALS CO LTD (KR) 2004-05-26 EP disclosed
EP-1257553-A1 PYRROLOPYRIMIDINONE DERIVATIVES, PROCESS OF PREPARATION AND USE SK Chemicals Co., Ltd. (KR) 2002-11-20 EP disclosed
WO-2001060825-A1 PYRROLOPYRIMIDINONE DERIVATIVES, PROCESS OF PREPARATION AND USE SK CHEMICALS CO., LTD. (KR) 2001-08-23 WO disclosed