Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 16/20 | 0.71 |
| ▸ | IMPDH1 | P20839 | 6/20 | 0.68 |
| ▸ | AAK1 | Q2M2I8 | 5/20 | 0.58 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.55 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.55 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.55 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.55 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.55 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.55 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.55 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.55 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.55 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6485191 | 0.91 | IMPDH2 (0.75) | IMPDH2IMPDH1AAK1 | |
| SCHEMBL6487162 | 0.90 | IMPDH2 (0.76) | IMPDH2IMPDH1AAK1 | |
| SCHEMBL6489003 | 0.90 | IMPDH2 (0.76) | IMPDH2IMPDH1AAK1 | |
| SCHEMBL6500037 | 0.90 | IMPDH2 (0.79) | IMPDH2IMPDH1AAK1 | |
| SCHEMBL6502204 | 0.90 | IMPDH2 (0.76) | IMPDH2IMPDH1AAK1 | |
| SCHEMBL1476132 | 0.89 | IMPDH2 (0.75) | IMPDH2IMPDH1AAK1 | |
| SCHEMBL6488704 | 0.89 | IMPDH2 (0.78) | IMPDH2IMPDH1AAK1 | |
| SCHEMBL6501517 | 0.89 | IMPDH2 (0.78) | IMPDH2IMPDH1AAK1 | |
| SCHEMBL6485918 | 0.89 | IMPDH2 (0.67) | IMPDH2IMPDH1AAK1HDAC3HDAC4 | |
| SCHEMBL6488779 | 0.89 | IMPDH2 (0.67) | IMPDH2IMPDH1AAK1HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6867299-B2 | Inosine monophosphate dehydrogenase (IMPDH); use as immunosuppressants, anticancer agents and antiviral agents | HOFFMANN-LA ROCHE INC. (US) | 2005-03-15 | — | — | US | disclosed |