Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 18/20 | 0.59 |
| ▸ | FLT1 | P17948 | 17/20 | 0.59 |
| ▸ | FGFR1 | P11362 | 16/20 | 0.59 |
| ▸ | EGFR | P00533 | 10/20 | 0.53 |
| ▸ | FLT4 | P35916 | 10/20 | 0.53 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.46 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.46 |
| ▸ | EPHB2 | P29323 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1468065 | 0.83 | FLT1 (0.77) | KDRFLT1FGFR1EGFRFLT4 | |
| Hydrochloric Acid SCHEMBL1469734 | 0.82 | FLT1 (0.78) | KDRFLT1FGFR1EGFRFLT4 | |
| SCHEMBL6487092 | 0.82 | KDR (0.51) | KDRFLT1FGFR1EGFRFLT4 | |
| SCHEMBL7864729 | 0.80 | KDR (0.73) | KDRFLT1FGFR1EGFRFLT4 | |
| SCHEMBL1890472 | 0.80 | KDR (0.62) | KDRFLT1FGFR1EGFRFLT4 | |
| Hydrochloric Acid SCHEMBL7859457 | 0.80 | KDR (0.72) | KDRFLT1FGFR1EGFRFLT4 | |
| Hydrochloric Acid SCHEMBL6485309 | 0.79 | KDR (0.58) | KDRFLT1FGFR1EGFRFLT4 | |
| SCHEMBL7864807 | 0.75 | KDR (1.00) | KDRFLT1FGFR1EGFRFLT4 | |
| SCHEMBL1886549 | 0.73 | KDR (0.75) | KDRFLT1FGFR1EGFRFLT4 | |
| SCHEMBL1468087 | 0.69 | FGFR1 (0.98) | KDRFLT1FGFR1EGFRFLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6897210-B2 | Quinazoline derivatives and pharmaceutical compositions containing them | ZENECA LIMITED (GB) | 2005-05-24 | — | — | US | disclosed |