Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 13/20 | 0.73 |
| ▸ | FGFR1 | P11362 | 9/20 | 0.73 |
| ▸ | FLT1 | P17948 | 9/20 | 0.73 |
| ▸ | EGFR | P00533 | 9/20 | 0.73 |
| ▸ | FLT4 | P35916 | 6/20 | 0.73 |
| ▸ | SRC | P12931 | 4/20 | 0.63 |
| ▸ | BRAF | P15056 | 4/20 | 0.63 |
| ▸ | TNNI3K | Q59H18 | 2/20 | 0.57 |
| ▸ | CIT | O14578 | 1/20 | 0.55 |
| ▸ | GAK | O14976 | 1/20 | 0.55 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.55 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.55 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.55 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.55 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.55 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.55 |
| ▸ | STK17B | O94768 | 1/20 | 0.55 |
| ▸ | STK10 | O94804 | 1/20 | 0.55 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.55 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL7859457 | 0.99 | KDR (0.72) | KDRFGFR1FLT1EGFRFLT4 | |
| SCHEMBL1151056 | 0.86 | EGFR (0.82) | KDRFLT1EGFRFLT4SRC | |
| Hydrochloric Acid SCHEMBL15565027 | 0.85 | EGFR (0.81) | KDRFLT1EGFRFLT4SRC | |
| SCHEMBL7857964 | 0.84 | KDR (1.00) | KDRFGFR1FLT1EGFRFLT4 | |
| Hydrochloric Acid SCHEMBL7870593 | 0.84 | KDR (0.98) | KDRFGFR1FLT1EGFRFLT4 | |
| SCHEMBL7866019 | 0.82 | KDR (1.00) | KDRFGFR1FLT1EGFRFLT4 | |
| Hydrochloric Acid SCHEMBL7864803 | 0.81 | KDR (0.98) | KDRFGFR1FLT1EGFRFLT4 | |
| SCHEMBL12694372 | 0.80 | AURKA (0.74) | KDREGFRSRCBRAFTNNI3K | |
| SCHEMBL6487089 | 0.80 | KDR (0.59) | KDRFGFR1FLT1EGFRFLT4 | |
| SCHEMBL7864646 | 0.80 | KDR (1.00) | KDRFGFR1FLT1EGFRFLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1116286-C | 4-anilinoquinazoline derivatives | ZENECA LTD (GB) | 2003-07-30 | — | — | CN | disclosed |
| EP-0885198-B1 | 4-ANILINOQUINAZOLINE DERIVATIVES | ASTRAZENECA AB (SE) | 2001-12-19 | — | — | EP | disclosed |
| US-6291455-B1 | PRODUCING AN ANTIANGIOGENIC AND/OR VASCULAR PERMEABILITY REDUCING EFFECT | ZENECA LIMITED (GB) | 2001-09-18 | — | — | US | disclosed |
| CN-1212684-A | 4-anilinoquinazoline derivatives | ZENECA LTD (GB) | 1999-03-31 | — | — | CN | disclosed |
| EP-0885198-A1 | 4-ANILINOQUINAZOLINE DERIVATIVES | ZENECA LIMITED (GB) | 1998-12-23 | — | — | EP | disclosed |
| WO-1997032856-A1 | 4-ANILINOQUINAZOLINE DERIVATIVES | ZENECA LIMITED (GB) | 1997-09-12 | — | — | WO | disclosed |