Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS3 | P29474 | 2/20 | 0.54 |
| ▸ | NOS1 | P29475 | 2/20 | 0.54 |
| ▸ | NOS2 | P35228 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | SLC1A3 | P43003 | 4/20 | 0.39 |
| ▸ | SLC1A2 | P43004 | 4/20 | 0.39 |
| ▸ | SLC1A1 | P43005 | 4/20 | 0.39 |
| ▸ | P2RY10 | O00398 | 2/20 | 0.39 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.39 |
| ▸ | GRIK1 | P39086 | 4/20 | 0.38 |
| ▸ | GRIK2 | Q13002 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.37 |
| ▸ | SLC7A11 | Q9UPY5 | 1/20 | 0.37 |
| ▸ | SLC1A5 | Q15758 | 1/20 | 0.37 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.36 |
| ▸ | GRIK3 | Q13003 | 1/20 | 0.36 |
| ▸ | GRIK5 | Q16478 | 1/20 | 0.36 |
| ▸ | IDO1 | P14902 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15992736 | 1.00 | NOS3 (0.54) | NOS3NOS1NOS2ALDH1A1TSHR | |
| SCHEMBL10698408 | 0.87 | — | — | |
| SCHEMBL1532102 | 0.87 | — | — | |
| SCHEMBL1287221 | 0.87 | — | — | |
| SCHEMBL25660616 | 0.84 | NOS3 (0.57) | NOS3NOS1NOS2ALDH1A1TSHR | |
| SCHEMBL9450989 | 0.84 | NOS3 (0.54) | NOS3NOS1NOS2SLC1A3SLC1A2 | |
| SCHEMBL1278536 | 0.84 | NOS3 (0.54) | NOS3NOS1NOS2SLC1A3SLC1A2 | |
| SCHEMBL9179525 | 0.84 | NOS3 (0.50) | NOS3NOS1NOS2SLC1A3SLC1A2 | |
| SCHEMBL9179523 | 0.84 | NOS3 (0.50) | NOS3NOS1NOS2SLC1A3SLC1A2 | |
| SCHEMBL24633956 | 0.83 | NOS3 (0.58) | NOS3NOS1NOS2SLC1A3SLC1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2017189715-A1 | MODIFIED PIGMENT EPITHELIUM-DERIVED FACTOR (PEDF) PEPTIDES AND USES THEREOF FOR TREATING NEOVASCULAR DISEASES, INFLAMMATORY DISEASES, CANCER, AND FOR CYTOPROTECTION | NORTHWESTERN UNIVERSITY (US) | 2017-11-02 | — | — | WO | disclosed |
| EP-3215189-A1 | POLYMER ADJUVANT | Oxford University Innovation Limited (GB) | 2017-09-13 | — | — | EP | disclosed |
| WO-2016055812-A1 | POLYMER ADJUVANT | ISIS INNOVATION LIMITED (GB) | 2016-04-14 | — | — | WO | disclosed |
| US-8138338-B2 | Aurora kinase inhibitors from an encoded small molecule library | GLAXOSMITHKLINE LLC (US) | 2012-03-20 | — | — | US | disclosed |
| US-8119798-B2 | P38 kinase inhibitors | GLAXOSMITHKLINE LLC (US) | 2012-02-21 | — | — | US | disclosed |
| US-20100120772-A1 | P38 KINASE INHIBITORS | GLAXOSMITHKLINE LLC | 2010-05-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100120772-A1 | P38 KINASE INHIBITORS | MAPK1, MAPK7, MAPKAPK2 | NOS3 327/4885NOS1 227/4885NOS2 167/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.