SCHEMBL6489408

SCHEMBL6489408

O=C(Nc1ccc(C[C@H](NC(=O)C2C3CCCCC3CN2S(=O)(=O)c2cccc(Cl)c2)C(=O)O)cc1)c1c(Cl)c[n+]([O-])cc1Cl.O=C(O)C1C2CCCCC2CN1S(=O)(=O)c1cccc(Cl)c1

nearest known ligand 0.61

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
ITGA4 P13612 20/20 0.61
ITGB1 P05556 11/20 0.61

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6477018 0.98 ITGA4 (0.63) ITGA4ITGB1
SCHEMBL6476178 0.93 ITGA4 (0.58) ITGA4ITGB1
SCHEMBL6477097 0.93 ITGA4 (0.58) ITGA4ITGB1
SCHEMBL6487038 0.84 ITGA4 (0.69) ITGA4ITGB1
SCHEMBL7747276 0.84 ITGA4 (0.69) ITGA4ITGB1
SCHEMBL6477907 0.84 ITGA4 (0.69) ITGA4ITGB1
SCHEMBL6476751 0.84 ITGA4 (0.69) ITGA4ITGB1
SCHEMBL6476986 0.83 ITGA4 (0.67) ITGA4ITGB1
SCHEMBL6477092 0.83 ITGA4 (0.71) ITGA4ITGB1
SCHEMBL8257295 0.83 ITGA4 (0.66) ITGA4ITGB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6855708-B2 N-arylsulfonyl aza-bicyclic derivatives as potent cell adhesion inhibitors MERCK & CO., INC. (US) 2005-02-15 US disclosed