Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 2/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | RAF1 | P04049 | 1/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.47 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.47 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.47 |
| ▸ | MAPK8 | P45983 | 6/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 6/20 | 0.43 |
| ▸ | AKT1 | P31749 | 1/20 | 0.41 |
| ▸ | IGF1R | P08069 | 2/20 | 0.41 |
| ▸ | VCP | P55072 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | CDC7 | O00311 | 1/20 | 0.39 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5453329 | 0.86 | KDM4E (0.47) | KDM4EGSK3BMAPK14ADORA1AKT1 | |
| SCHEMBL5455132 | 0.84 | MAPK14 (0.48) | KDM4EGSK3BMAPK14ADORA1AKT1 | |
| SCHEMBL5398657 | 0.81 | MAPK9 (0.56) | GSK3BMAPK14EGFRRAF1ADORA3 | |
| SCHEMBL5457541 | 0.80 | KDM4E (0.42) | KDM4EGSK3BMAPK14ADORA1AKT1 | |
| SCHEMBL6501891 | 0.80 | MAPK14 (0.48) | GSK3BMAPK14EGFRRAF1ADORA3 | |
| SCHEMBL5457552 | 0.79 | KDM4E (0.51) | KDM4EMAPK14EGFRMAPK8MAPK9 | |
| SCHEMBL14339923 | 0.79 | KDM4E (0.41) | KDM4EGSK3BMAPK14AKT1VCP | |
| Hydrochloric Acid SCHEMBL5454770 | 0.79 | KDM4E (0.50) | KDM4EMAPK14EGFRMAPK8MAPK9 | |
| SCHEMBL5214203 | 0.77 | MAPK9 (0.48) | MAPK8MAPK9 | |
| SCHEMBL5214451 | 0.75 | CSNK1D (0.51) | GSK3BMAPK14MAPK8MAPK9MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050107400-A1 | Use of pyrazolopyridines as therapeutic compounds | SMITHKLINE BEECHAM CORPORATION | 2005-05-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050107400-A1 | Use of pyrazolopyridines as therapeutic compounds | QDPR, DPYD, ENTPD5 | KDM4E 3044/4885GSK3B 3047/4885MAPK14 1551/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.