Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.61 |
| ▸ | POLB | P06746 | 6/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.61 |
| ▸ | GAA | P10253 | 3/20 | 0.61 |
| ▸ | RAD52 | P43351 | 3/20 | 0.61 |
| ▸ | LMNA | P02545 | 3/20 | 0.61 |
| ▸ | MITF | O75030 | 2/20 | 0.61 |
| ▸ | GLA | P06280 | 2/20 | 0.61 |
| ▸ | RAB9A | P51151 | 2/20 | 0.61 |
| ▸ | TTR | P02766 | 1/20 | 0.61 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.55 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.49 |
| ▸ | HTT | P42858 | 3/20 | 0.49 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.49 |
| ▸ | CBFB | Q13951 | 1/20 | 0.49 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.49 |
| ▸ | TERT | O14746 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL10728396 | 0.98 | POLB (0.59) | KDM4EPOLBALDH1A1GAARAD52 | |
| SCHEMBL10728537 | 0.91 | POLB (0.63) | KDM4EPOLBALDH1A1GAARAD52 | |
| SCHEMBL4313700 | 0.90 | POLB (0.57) | KDM4EPOLBALDH1A1GAARAD52 | |
| SCHEMBL12665011 | 0.87 | POLB (0.44) | KDM4EPOLBALDH1A1GAARAD52 | |
| SCHEMBL3170264 | 0.86 | KMT2A (0.46) | KDM4EPOLBALDH1A1GAARAD52 | |
| SCHEMBL6096807 | 0.86 | HTR1A (0.51) | POLBRAD52HRH3SLC2A1 | |
| SCHEMBL3641050 | 0.84 | POLB (0.41) | KDM4EPOLBALDH1A1GAARAD52 | |
| SCHEMBL18843434 | 0.84 | APP (0.50) | KDM4EPOLBALDH1A1GAARAD52 | |
| SCHEMBL7218710 | 0.83 | POLB (0.45) | KDM4EPOLBALDH1A1GAARAD52 | |
| SCHEMBL9602738 | 0.82 | APP (0.55) | KDM4EPOLBGAALMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108003153-B | Nitrogen-containing five-membered heterocyclic quinoline compound and salt, preparation method, pharmaceutical composition and application thereof | 中国医学科学院肿瘤医院 | 2021-04-30 | — | — | CN | disclosed |
| CN-108003153-A | Nitrogenous five-ring heterocycles and quinolines and its salt, preparation method, pharmaceutical composition and purposes | 中国医学科学院肿瘤医院 | 2018-05-08 | — | — | CN | disclosed |
| US-9765071-B2 | Substituted imidazo ring systems and methods | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2017-09-19 | — | — | US | disclosed |
| US-20160194322-A1 | SUBSTITUTED IMIDAZO RING SYSTEMS AND METHODS | 3M INNOVATIVE PROPERTIES CO (US) | 2016-07-07 | — | — | US | disclosed |
| US-9328110-B2 | Substituted imidazo ring systems and methods | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2016-05-03 | — | — | US | disclosed |
| US-20140194628-A1 | SUBSTITUTED IMIDAZO RING SYSTEMS AND METHODS | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2014-07-10 | — | — | US | disclosed |
| US-6916925-B1 | Dye labeled imidazoquinoline compounds | 3M INNOVATIVE PROPERTIES CO. (US) | 2005-07-12 | — | — | US | disclosed |
| EP-1228147-B1 | DYE LABELED IMIDAZOQUINOLINE COMPOUNDS | 3M INNOVATIVE PROPERTIES CO (US) | 2004-02-04 | — | — | EP | disclosed |
| US-6630588-B2 | Imidazonaphthyridine, imidazopyridine and imidazoquinoline compounds that have immune response modulating activity and that contain a dye moiety, in particular, a fluorescent dye moiety, e.g., dipyrrometheneboron difluoride dyes | 3M INNOVATIVE PROPERTIES COMPANY | 2003-10-07 | — | — | US | disclosed |
| US-20020120141-A1 | Dye labeled imidazoquinoline compounds | 3M INNOVATIVE PROPERTIES COMPANY | 2002-08-29 | — | — | US | disclosed |
| EP-1228147-A1 | DYE LABELED IMIDAZOQUINOLINE COMPOUNDS | 3M Innovative Properties Company (US) | 2002-08-07 | — | — | EP | disclosed |
| US-6376669-B1 | COMPLEXES | 3M INNOVATIVE PROPERTIES COMPANY | 2002-04-23 | — | — | US | disclosed |
| WO-2001034709-A1 | DYE LABELED IMIDAZOQUINOLINE COMPOUNDS | 3M INNOVATIVE PROPERTIES COMPANY (US) | 2001-05-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160194322-A1 | SUBSTITUTED IMIDAZO RING SYSTEMS AND METHODS | IL2, IRF3, EIF2AK2 | KDM4E 3681/4885POLB 1872/4885ALDH1A1 1659/4885 |
| US-20020120141-A1 | Dye labeled imidazoquinoline compounds | LY96, CD74, IFNAR1 | KDM4E 3326/4885POLB 3400/4885ALDH1A1 1521/4885 |
| US-20140194628-A1 | SUBSTITUTED IMIDAZO RING SYSTEMS AND METHODS | IL2, IRF3, EIF2AK2 | KDM4E 3681/4885POLB 1872/4885ALDH1A1 1659/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.