Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | ACSS2 | Q9NR19 | 1/20 | 0.44 |
| ▸ | METAP2 | P50579 | 1/20 | 0.44 |
| ▸ | METAP1 | P53582 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6479789 | 0.89 | SMN1; SMN2 (0.59) | SMN1; SMN2ALOX15ATMMAPK1KDM4E | |
| SCHEMBL5851401 | 0.87 | SMN1; SMN2 (0.55) | SMN1; SMN2ALOX15ATMMAPK1KDM4E | |
| SCHEMBL30034162 | 0.87 | SMN1; SMN2 (0.55) | SMN1; SMN2ALOX15ATMMAPK1KDM4E | |
| SCHEMBL6479700 | 0.85 | SMN1; SMN2 (0.58) | SMN1; SMN2ALOX15ATMKDM4EALDH1A1 | |
| SCHEMBL18784479 | 0.84 | SMN1; SMN2 (0.52) | SMN1; SMN2ALOX15ATMMAPK1KDM4E | |
| SCHEMBL38664142 | 0.81 | ALOX15 (0.57) | SMN1; SMN2ALOX15ATMMAPK1KDM4E | |
| SCHEMBL10969560 | 0.81 | SMN1; SMN2 (0.57) | SMN1; SMN2ALOX15ATMKDM4EALDH1A1 | |
| SCHEMBL6493311 | 0.80 | MAPK1 (0.44) | SMN1; SMN2ATMMAPK1KDM4EALDH1A1 | |
| SCHEMBL8799913 | 0.79 | SMN1; SMN2 (0.60) | SMN1; SMN2ALOX15ATMKDM4EALDH1A1 | |
| SCHEMBL13104750 | 0.79 | SMN1; SMN2 (0.52) | SMN1; SMN2ALOX15ATMKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023161940-A1 | APOPTOSIS RELATED PROTEIN IN THE TGF-BETA SIGNALING PATHWAY (ARTS) MIMETIC COMPOUNDS, COMPOSITIONS, METHODS AND USES THEREOF IN INDUCTION OF APOPTOSIS | CARMEL-HAIFA UNIVERSITY ECONOMIC CORPORATION LTD. (IL) | 2023-08-31 | — | — | WO | disclosed |
| US-6962938-B2 | Spiro-cyclic β-amino acid derivatives as inhibitors of matrix metalloproteases and TNF-α converting enzyme (TACE) | BRISTOL-MYERS SQUIBB PHARMA COMPANY (US) | 2005-11-08 | — | — | US | disclosed |
| US-6720329-B2 | ANTIINFLAMMATORY AGENTS | BRISTOL-MYERS SQUIBB PHARMA | 2004-04-13 | — | — | US | disclosed |