Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 20/20 | 0.52 |
| ▸ | HDAC2 | Q92769 | 19/20 | 0.52 |
| ▸ | HDAC6 | Q9UBN7 | 19/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 18/20 | 0.52 |
| ▸ | HDAC4 | P56524 | 18/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 18/20 | 0.52 |
| ▸ | HDAC10 | Q969S8 | 18/20 | 0.52 |
| ▸ | HDAC11 | Q96DB2 | 18/20 | 0.52 |
| ▸ | HDAC8 | Q9BY41 | 18/20 | 0.52 |
| ▸ | HDAC9 | Q9UKV0 | 18/20 | 0.52 |
| ▸ | HDAC5 | Q9UQL6 | 18/20 | 0.52 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | PDE4A | P27815 | 1/20 | 0.46 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.46 |
| ▸ | HTR6 | P50406 | 1/20 | 0.46 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.46 |
| ▸ | ASPH | Q12797 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4522246 | 0.88 | HDAC1 (0.54) | HDAC1HDAC2HDAC6HDAC3HDAC4 | |
| SCHEMBL1377816 | 0.84 | HDAC1 (0.70) | HDAC1HDAC2HDAC6HDAC3HDAC4 | |
| SCHEMBL1377818 | 0.84 | HDAC1 (0.70) | HDAC1HDAC2HDAC6HDAC3HDAC4 | |
| SCHEMBL4508022 | 0.78 | HDAC1 (0.72) | HDAC1HDAC2HDAC6HDAC3HDAC4 | |
| SCHEMBL1376427 | 0.73 | HDAC1 (0.72) | HDAC1HDAC2HDAC6HDAC3HDAC4 | |
| SCHEMBL1376464 | 0.73 | HDAC1 (0.72) | HDAC1HDAC2HDAC6HDAC3HDAC4 | |
| SCHEMBL1376403 | 0.73 | HDAC1 (0.73) | HDAC1HDAC2HDAC6HDAC3HDAC4 | |
| SCHEMBL1376467 | 0.73 | HDAC1 (0.72) | HDAC1HDAC2HDAC6HDAC3HDAC4 | |
| SCHEMBL1376425 | 0.73 | HDAC1 (0.72) | HDAC1HDAC2HDAC6HDAC3HDAC4 | |
| SCHEMBL1376399 | 0.73 | HDAC1 (0.73) | HDAC1HDAC2HDAC6HDAC3HDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050143385-A1 | Carbamic acid compounds comprising a piperazine linkage as hdac inhibitors | TOPOTARGET UK LIMITED (GB) | 2005-06-30 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050143385-A1 | Carbamic acid compounds comprising a piperazine linkage as hdac inhibitors | HDAC1, HDAC7, HDAC11 | HDAC1 1/4885HDAC2 6/4885HDAC6 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.