Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 13/20 | 0.46 |
| ▸ | CA1 | P00915 | 4/20 | 0.36 |
| ▸ | CA2 | P00918 | 4/20 | 0.36 |
| ▸ | CA4 | P22748 | 2/20 | 0.36 |
| ▸ | CA7 | P43166 | 2/20 | 0.36 |
| ▸ | CA12 | O43570 | 3/20 | 0.35 |
| ▸ | CA9 | Q16790 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5731668 | 1.00 | HMGCR (0.46) | HMGCRCA1CA2CA4CA7 | |
| SCHEMBL5731672 | 1.00 | HMGCR (0.46) | HMGCRCA1CA2CA4CA7 | |
| SCHEMBL6493452 | 1.00 | HMGCR (0.46) | HMGCRCA1CA2CA4CA7 | |
| SCHEMBL5732350 | 0.94 | HMGCR (0.42) | HMGCR | |
| SCHEMBL5732349 | 0.94 | HMGCR (0.42) | HMGCR | |
| SCHEMBL5749944 | 0.91 | HMGCR (0.43) | HMGCRCA1CA2CA4CA7 | |
| SCHEMBL5749941 | 0.91 | HMGCR (0.43) | HMGCRCA1CA2CA4CA7 | |
| SCHEMBL5730680 | 0.90 | HMGCR (0.45) | HMGCR | |
| SCHEMBL5730679 | 0.90 | HMGCR (0.45) | HMGCR | |
| SCHEMBL6503852 | 0.90 | HMGCR (0.37) | HMGCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20050154042-A1 | N-alkyl pyrroles as HMG-CoA reductase inhibitors | WARNER-LAMBERT COMPANY | 2005-07-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050154042-A1 | N-alkyl pyrroles as HMG-CoA reductase inhibitors | HMGCR, DHCR7, CYP11A1 | HMGCR 1/4885CA1 4307/4885CA2 4591/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.