Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 1/20 | 0.49 |
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | HTR2C | P28335 | 2/20 | 0.36 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL650148 | 0.87 | C5AR1 (0.48) | C5AR1PTGDR2CYP2C9CYP2C19CYP2C8 | |
| SCHEMBL651031 | 0.86 | C5AR1 (0.48) | C5AR1PTGDR2CYP2C9CYP2C19CYP2C8 | |
| SCHEMBL648948 | 0.84 | C5AR1 (0.50) | C5AR1PTGDR2CYP2C9CYP2C19CYP2C8 | |
| SCHEMBL650146 | 0.84 | C5AR1 (0.51) | C5AR1PTGDR2CYP2C9CYP2C19CYP2C8 | |
| SCHEMBL651208 | 0.83 | C5AR1 (0.49) | C5AR1PTGDR2CYP2C9CYP2C19CYP2C8 | |
| SCHEMBL652376 | 0.81 | C5AR1 (0.58) | C5AR1PTGDR2CYP2C9CYP2C19CYP2C8 | |
| SCHEMBL1913082 | 0.81 | C5AR1 (0.49) | C5AR1PTGDR2CYP2C9CYP2C19CYP2C8 | |
| SCHEMBL1913084 | 0.81 | C5AR1 (0.51) | C5AR1PTGDR2CYP2C9CYP2C19CYP2C8 | |
| SCHEMBL648949 | 0.80 | PTGDR2 (0.51) | C5AR1PTGDR2CYP2C9CYP2C19CYP2C8 | |
| SCHEMBL651214 | 0.80 | C5AR1 (0.50) | C5AR1PTGDR2CYP2C9CYP2C19CYP2C8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |