Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 1/20 | 0.48 |
| ▸ | PTGDR2 | Q9Y5Y4 | 4/20 | 0.38 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.34 |
| ▸ | PKM | P14618 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL648948 | 0.90 | C5AR1 (0.50) | C5AR1PTGDR2CYP2C8CYP2C9CYP2C19 | |
| SCHEMBL650148 | 0.90 | C5AR1 (0.48) | C5AR1PTGDR2CYP2C8CYP2C9CYP2C19 | |
| SCHEMBL650146 | 0.90 | C5AR1 (0.51) | C5AR1PTGDR2CYP2C8CYP2C9CYP2C19 | |
| SCHEMBL651208 | 0.88 | C5AR1 (0.49) | C5AR1PTGDR2CYP2C8CYP2C9CYP2C19 | |
| SCHEMBL649602 | 0.87 | C5AR1 (0.51) | C5AR1PTGDR2CYP2C8CYP2C9CYP2C19 | |
| SCHEMBL652376 | 0.86 | C5AR1 (0.58) | C5AR1PTGDR2CYP2C8CYP2C9CYP2C19 | |
| SCHEMBL649353 | 0.86 | C5AR1 (0.49) | C5AR1PTGDR2CYP2C8CYP2C9CYP2C19 | |
| SCHEMBL651713 | 0.85 | C5AR1 (0.49) | C5AR1PTGDR2CYP2C8CYP2C9CYP2C19 | |
| SCHEMBL1912840 | 0.85 | C5AR1 (0.63) | C5AR1TSHRPPARGPPARAALDH1A1 | |
| SCHEMBL1913082 | 0.85 | C5AR1 (0.49) | C5AR1PTGDR2CYP2C8CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8119665-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NOVARTIS INTERNATIONAL PHARMACEUTICAL LTD. (BM) | 2012-02-21 | — | — | US | disclosed |
| US-7186734-B2 | Aryl imidazoles and related compounds as C5a receptor modulators | NEUROGEN CORPORATION (US) | 2007-03-06 | — | — | US | disclosed |