Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IMPDH2 | P12268 | 18/20 | 0.74 |
| ▸ | IMPDH1 | P20839 | 6/20 | 0.70 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.59 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.59 |
| ▸ | AAK1 | Q2M2I8 | 2/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6485950 | 0.91 | IMPDH2 (0.74) | IMPDH2IMPDH1ROCK2ROCK1AAK1 | |
| SCHEMBL6501517 | 0.88 | IMPDH2 (0.78) | IMPDH2IMPDH1AAK1 | |
| SCHEMBL6485901 | 0.88 | IMPDH2 (0.68) | IMPDH2IMPDH1ROCK2ROCK1AAK1 | |
| SCHEMBL6496761 | 0.87 | IMPDH2 (0.65) | IMPDH2IMPDH1ROCK2ROCK1AAK1 | |
| SCHEMBL6486424 | 0.86 | IMPDH2 (0.69) | IMPDH2IMPDH1ROCK2ROCK1AAK1 | |
| SCHEMBL6486532 | 0.86 | IMPDH2 (0.66) | IMPDH2IMPDH1AAK1 | |
| SCHEMBL6487162 | 0.86 | IMPDH2 (0.76) | IMPDH2IMPDH1AAK1 | |
| SCHEMBL6486480 | 0.85 | IMPDH2 (0.73) | IMPDH2IMPDH1AAK1 | |
| SCHEMBL1473286 | 0.85 | IMPDH2 (1.00) | IMPDH2IMPDH1AAK1 | |
| SCHEMBL1474188 | 0.85 | IMPDH2 (0.85) | IMPDH2IMPDH1AAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6867299-B2 | Inosine monophosphate dehydrogenase (IMPDH); use as immunosuppressants, anticancer agents and antiviral agents | HOFFMANN-LA ROCHE INC. (US) | 2005-03-15 | — | — | US | disclosed |