Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK1 | Q13464 | 6/20 | 0.43 |
| ▸ | PRKG1 | Q13976 | 5/20 | 0.43 |
| ▸ | PRKACA | P17612 | 3/20 | 0.43 |
| ▸ | GSK3A | P49840 | 3/20 | 0.43 |
| ▸ | GSK3B | P49841 | 3/20 | 0.43 |
| ▸ | PRKX | P51817 | 3/20 | 0.43 |
| ▸ | RPS6KA5 | O75582 | 2/20 | 0.43 |
| ▸ | PRKCG | P05129 | 2/20 | 0.43 |
| ▸ | CDK1 | P06493 | 2/20 | 0.43 |
| ▸ | RPS6KB1 | P23443 | 2/20 | 0.43 |
| ▸ | CDK2 | P24941 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | AKT2 | P31751 | 2/20 | 0.43 |
| ▸ | IRAK1 | P51617 | 2/20 | 0.43 |
| ▸ | NEK4 | P51957 | 2/20 | 0.43 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.43 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.43 |
| ▸ | PRKG2 | Q13237 | 2/20 | 0.43 |
| ▸ | PKN2 | Q16513 | 2/20 | 0.43 |
| ▸ | CDC42BPA | Q5VT25 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6494427 | 1.00 | ROCK1 (0.43) | ROCK1PRKG1PRKACAGSK3AGSK3B | |
| SCHEMBL6486981 | 0.91 | ROCK2 (0.41) | ROCK1PRKG1PRKACAGSK3AGSK3B | |
| SCHEMBL6486983 | 0.91 | ROCK2 (0.41) | ROCK1PRKG1PRKACAGSK3AGSK3B | |
| SCHEMBL6202933 | 0.91 | ROCK1 (0.44) | ROCK1PRKG1PRKACAGSK3AGSK3B | |
| SCHEMBL6489820 | 0.91 | ROCK1 (0.44) | ROCK1PRKG1PRKACAGSK3AGSK3B | |
| SCHEMBL6487454 | 0.91 | ROCK1 (0.44) | ROCK1PRKG1PRKACAGSK3AGSK3B | |
| SCHEMBL6487452 | 0.91 | ROCK1 (0.44) | ROCK1PRKG1PRKACAGSK3AGSK3B | |
| SCHEMBL6205752 | 0.89 | ROCK1 (0.46) | ROCK1PRKG1PRKACAGSK3AGSK3B | |
| SCHEMBL6205757 | 0.89 | ROCK1 (0.46) | ROCK1PRKG1PRKACAGSK3AGSK3B | |
| SCHEMBL6205754 | 0.89 | ROCK1 (0.46) | ROCK1PRKG1PRKACAGSK3AGSK3B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6900210-B2 | Pyridinyl, pyrimidinyl and pyrazinyl amides as potassium channel openers | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-05-31 | — | — | US | disclosed |