Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB2 | P05107 | 10/20 | 0.53 |
| ▸ | ICAM1 | P05362 | 10/20 | 0.53 |
| ▸ | ITGAL | P20701 | 10/20 | 0.53 |
| ▸ | MAPT | P10636 | 7/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 1/20 | 0.46 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.46 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.46 |
| ▸ | CAPN1 | P07384 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6494761 | 1.00 | ITGB2 (0.53) | ITGB2ICAM1ITGALMAPTKMT2A | |
| SCHEMBL6498627 | 0.88 | ITGB2 (0.51) | ITGB2ICAM1ITGALMAPTKMT2A | |
| SCHEMBL6498635 | 0.88 | ITGB2 (0.51) | ITGB2ICAM1ITGALMAPTKMT2A | |
| SCHEMBL8296927 | 0.88 | ITGB2 (0.51) | ITGB2ICAM1ITGALMAPTKMT2A | |
| SCHEMBL6506032 | 0.84 | POLB (0.49) | ITGB2ICAM1ITGALMAPTKMT2A | |
| SCHEMBL6506038 | 0.84 | POLB (0.49) | ITGB2ICAM1ITGALMAPTKMT2A | |
| SCHEMBL6495203 | 0.81 | CAPN1 (0.49) | ITGB2ICAM1ITGALKMT2AMEN1 | |
| SCHEMBL8296935 | 0.81 | CAPN1 (0.49) | ITGB2ICAM1ITGALKMT2AMEN1 | |
| SCHEMBL6495207 | 0.81 | CAPN1 (0.49) | ITGB2ICAM1ITGALKMT2AMEN1 | |
| SCHEMBL6503994 | 0.81 | CAPN1 (0.45) | ITGB2ICAM1ITGALMAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005016883-A2 | ACRYLAMIDE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-02-24 | — | — | WO | claimed |
| WO-2005016883-A2 | ACRYLAMIDE DERIVATIVES AS VLA-1 INTEGRIN ANTAGONISTS AND USES THEREOF | ICOS CORPORATION (US) | 2005-02-24 | — | — | WO | disclosed |