Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.60 |
| ▸ | NCF1 | P14598 | 4/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | GALR3 | O60755 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6985541 | 0.85 | CYP1A2 (0.60) | CYP1A2NCF1CYP2C19KDM4ESMN1; SMN2 | |
| SCHEMBL8232676 | 0.82 | CYP1A2 (0.62) | CYP1A2NCF1CYP2C19KDM4ESMN1; SMN2 | |
| SCHEMBL1366357 | 0.82 | CYP1A2 (0.62) | CYP1A2NCF1CYP2C19KDM4ESMN1; SMN2 | |
| SCHEMBL5898542 | 0.81 | CYP1A2 (0.60) | CYP1A2NCF1CYP2C19KDM4ESMN1; SMN2 | |
| SCHEMBL994597 | 0.81 | CYP1A2 (0.60) | CYP1A2NCF1CYP2C19KDM4ESMN1; SMN2 | |
| SCHEMBL3921968 | 0.81 | CYP1A2 (0.60) | CYP1A2NCF1CYP2C19KDM4ESMN1; SMN2 | |
| SCHEMBL3964916 | 0.81 | CYP1A2 (0.60) | CYP1A2NCF1CYP2C19KDM4ESMN1; SMN2 | |
| SCHEMBL6494921 | 0.81 | CYP1A2 (0.60) | CYP1A2NCF1CYP2C19KDM4ESMN1; SMN2 | |
| SCHEMBL265139 | 0.81 | NCF1 (0.61) | CYP1A2NCF1CYP2C19KDM4ESMN1; SMN2 | |
| SCHEMBL18535317 | 0.79 | CYP1A2 (0.58) | CYP1A2NCF1CYP2C19KDM4ESMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6884806-B2 | Bicyclic lactam derivatives as inhibitors of matrix metalloproteinases and/or TNF-α converting enzyme (TACE) | BRISTOL-MYERS SQUIBB COMPANY (US) | 2005-04-26 | — | — | US | disclosed |